Protein sprouty homolog 2
The SPRY2 gene encodes a protein that is involved in various signal transduction processes. Mutations cause autosomal dominant IgA nephropathy type 3.
Genetests:
Related Diseases:
References:
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Hacohen N et al. (1998) sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways.
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Tang N et al. (2011) Control of mitotic spindle angle by the RAS-regulated ERK1/2 pathway determines lung tube shape.
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Metzger RJ et al. (2008) The branching programme of mouse lung development.
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Klein OD et al. (2006) Sprouty genes control diastema tooth development via bidirectional antagonism of epithelial-mesenchymal FGF signaling.
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Taketomi T et al. (2005) Loss of mammalian Sprouty2 leads to enteric neuronal hyperplasia and esophageal achalasia.
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Shim K et al. (2005) Sprouty2, a mouse deafness gene, regulates cell fate decisions in the auditory sensory epithelium by antagonizing FGF signaling.
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Ding W et al. (2003) Functional analysis of the human Sprouty2 gene promoter.
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Hanafusa H et al. (2002) Sprouty1 and Sprouty2 provide a control mechanism for the Ras/MAPK signalling pathway.
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Lim J et al. (2002) The cysteine-rich sprouty translocation domain targets mitogen-activated protein kinase inhibitory proteins to phosphatidylinositol 4,5-bisphosphate in plasma membranes.
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Egan JE et al. (2002) The bimodal regulation of epidermal growth factor signaling by human Sprouty proteins.
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Yusoff P et al. (2002) Sprouty2 inhibits the Ras/MAP kinase pathway by inhibiting the activation of Raf.
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Gross I et al. (2001) Mammalian sprouty proteins inhibit cell growth and differentiation by preventing ras activation.
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Lim J et al. (2000) Sprouty proteins are targeted to membrane ruffles upon growth factor receptor tyrosine kinase activation. Identification of a novel translocation domain.
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Milillo A et al. (2015) A SPRY2 mutation leading to MAPK/ERK pathway inhibition is associated with an autosomal dominant form of IgA nephropathy.
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NCBI article
NCBI 10253
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OMIM.ORG article
Omim 602466
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Wikipedia article
Wikipedia EN (SPRY2)
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Update: Aug. 14, 2020