Protein sel-1 homolog 1
The SEL1L gene encodes a protein involved in clearance of misfolded proteins in the cytoplasm. Evidence exists that it may play a role in inflammatory bowel disease.
Genetests:
Research |
Method |
Carrier testing |
Turnaround |
5 days |
Specimen type |
genomic DNA |
Related Diseases:
References:
1. |
Grant B et al. (1996) The Caenorhabditis elegans sel-1 gene, a negative regulator of lin-12 and glp-1, encodes a predicted extracellular protein.
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2. |
Grant B et al. (1997) Structure, function, and expression of SEL-1, a negative regulator of LIN-12 and GLP-1 in C. elegans.
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3. |
Biunno I et al. (1997) Isolation of a pancreas-specific gene located on human chromosome 14q31: expression analysis in human pancreatic ductal carcinomas.
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4. |
Donoviel DB et al. (1999) SEL-1L maps to human chromosome 14, near the insulin-dependent diabetes mellitus locus 11.
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5. |
Harada Y et al. (1999) Complete cDNA sequence and genomic organization of a human pancreas-specific gene homologous to Caenorhabditis elegans sel-1.
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6. |
Cattaneo M et al. (2004) Identification of a region within SEL1L protein required for tumour growth inhibition.
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7. |
Odom DT et al. (2007) Tissue-specific transcriptional regulation has diverged significantly between human and mouse.
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8. |
Kaneko M et al. (2007) A different pathway in the endoplasmic reticulum stress-induced expression of human HRD1 and SEL1 genes.
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9. |
Mueller B et al. (2008) SEL1L nucleates a protein complex required for dislocation of misfolded glycoproteins.
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10. |
Francisco AB et al. (2011) Haploid insufficiency of suppressor enhancer Lin12 1-like (SEL1L) protein predisposes mice to high fat diet-induced hyperglycemia.
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11. |
Sun S et al. (2016) Epithelial Sel1L is required for the maintenance of intestinal homeostasis.
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12. |
Hosokawa N et al. (2016) Association of the SEL1L protein transmembrane domain with HRD1 ubiquitin ligase regulates ERAD-L.
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13. |
NCBI article
NCBI 6400
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14. |
OMIM.ORG article
Omim 602329
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15. |
Wikipedia article
Wikipedia EN (SEL1L)
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Update: Aug. 14, 2020