Complement receptor type 2
The CR2 gene encodes a complement receptor expressed on B lymphocytes which also binds Epstein-Barr virus. Mutations cause autosomal recessive variable immunodeficiency type 7 and susceptibility to lupus erythematodes.
Genetests:
Research |
Method |
Carrier testing |
Turnaround |
5 days |
Specimen type |
genomic DNA |
Related Diseases:
References:
1. |
Weis JH et al. (1987) A complement receptor locus: genes encoding C3b/C4b receptor and C3d/Epstein-Barr virus receptor map to 1q32.
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2. |
Barrington RA et al. (2009) Uncoupling CD21 and CD19 of the B-cell coreceptor.
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3. |
Asokan R et al. (2006) Characterization of human complement receptor type 2 (CR2/CD21) as a receptor for IFN-alpha: a potential role in systemic lupus erythematosus.
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4. |
Prota AE et al. (2002) The crystal structure of human CD21: Implications for Epstein-Barr virus and C3d binding.
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5. |
Szakonyi G et al. (2001) Structure of complement receptor 2 in complex with its C3d ligand.
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6. |
Weis JJ et al. (1984) Identification of a 145,000 Mr membrane protein as the C3d receptor (CR2) of human B lymphocytes.
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7. |
Rodriguez de Cordoba S et al. (1986) Quantitative variations of the C3b/C4b receptor (CR1) in human erythrocytes are controlled by genes within the regulator of complement activation (RCA) gene cluster.
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8. |
Moore MD et al. (1987) Molecular cloning of the cDNA encoding the Epstein-Barr virus/C3d receptor (complement receptor type 2) of human B lymphocytes.
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9. |
Yefenof E et al. (1976) Surface markers on human B and T-lymphocytes. IX. Two-color immunofluorescence studies on the association between ebv receptors and complement receptors on the surface of lymphoid cell lines.
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10. |
Thiel J et al. (2012) Genetic CD21 deficiency is associated with hypogammaglobulinemia.
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11. |
Wu H et al. (2007) Association of a common complement receptor 2 haplotype with increased risk of systemic lupus erythematosus.
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12. |
Fairweather D et al. (2006) Complement receptor 1 and 2 deficiency increases coxsackievirus B3-induced myocarditis, dilated cardiomyopathy, and heart failure by increasing macrophages, IL-1beta, and immune complex deposition in the heart.
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13. |
Rodriguez de Cordoba S et al. (1985) Human genes for three complement components that regulate the activation of C3 are tightly linked.
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14. |
Orphanet article
Orphanet ID 160142
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15. |
NCBI article
NCBI 1380
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16. |
OMIM.ORG article
Omim 120650
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17. |
Wikipedia article
Wikipedia EN (Complement_receptor_2)
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Update: Aug. 14, 2020