Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders
The SLC2A5 gene encodes a monosaccharide tranporter with fructose affinity. If this transporter is deficient in intestinal brush border cells gastrointestinal symptoms may arise after consumption of significant amounts of fructose.
| Clinic | Method | Carrier testing |
| Turnaround | 5 days | |
| Specimen type | genomic DNA |
| Clinic | Method | Genomic sequencing of the entire coding region |
| Turnaround | 25 days | |
| Specimen type | genomic DNA |
| 1. |
Davidson NO et al. (1992) Human intestinal glucose transporter expression and localization of GLUT5. 
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| 2. |
Burant CF et al. (1992) Fructose transporter in human spermatozoa and small intestine is GLUT5.
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| 3. |
Kayano T et al. (1990) Human facilitative glucose transporters. Isolation, functional characterization, and gene localization of cDNAs encoding an isoform (GLUT5) expressed in small intestine, kidney, muscle, and adipose tissue and an unusual glucose transporter pseudogene-like sequence (GLUT6).
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| 4. |
Jones HF et al. (2011) Intestinal fructose transport and malabsorption in humans.
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| 5. |
White PS et al. (1998) Physical mapping of the CA6, ENO1, and SLC2A5 (GLUT5) genes and reassignment of SLC2A5 to 1p36.2.
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| 6. |
OMIM.ORG article Omim 138230
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| 7. |
NCBI article NCBI 6518
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| 8. |
Wikipedia article Wikipedia EN (GLUT5)
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