Solute carrier family 26, member 6

The gene product of the SLC26A6 is an oxalate transporter. Mutations in this gene are probably responsible for nephrolithiasis that is associatedwith chronic diarrhea.

Genetests:

Research	Method	Carrier testing
	Turnaround	5 days
	Specimen type	genomic DNA

Clinic	Method	Massive parallel sequencing
	Turnaround	25 days
	Specimen type	genomic DNA

Clinic	Method	Genomic sequencing of the entire coding region
	Turnaround	25 days
	Specimen type	genomic DNA

Related Diseases:

Nephrolithiasis diarrhea syndrome
	SLC26A6

References:

1.	Jiang Z et al. (2006) Calcium oxalate urolithiasis in mice lacking anion transporter Slc26a6.

2.	None (2006) A key stone cop regulates oxalate homeostasis.

3.	None (2009) Recent advances in the pathophysiology of nephrolithiasis.

4.	Lohi H et al. (2000) Mapping of five new putative anion transporter genes in human and characterization of SLC26A6, a candidate gene for pancreatic anion exchanger.

5.	Waldegger S et al. (2001) Cloning and characterization of SLC26A6, a novel member of the solute carrier 26 gene family.

6.	Chernova MN et al. (2005) Functional comparison of mouse slc26a6 anion exchanger with human SLC26A6 polypeptide variants: differences in anion selectivity, regulation, and electrogenicity.

7.	Markovich D et al. (2007) Specificity and regulation of renal sulfate transporters.

8.	Soleimani M et al. (2006) SLC26 chloride/base exchangers in the kidney in health and disease.

9.	None (2006) Overview of the SLC26 family and associated diseases.

10.	Sindić A et al. (2007) Renal physiology of SLC26 anion exchangers.

11.	NCBI article NCBI 65010

12.	OMIM.ORG article Omim 610068

13.	Wikipedia article Wikipedia EN (SLC26A6)

Update: Aug. 14, 2020

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