The most important mesangioproliferative glomerulonephritis is IgA nephropathy. Therefore in many textbooks it is considered as one and the same disease. However, the fact that mesangioproloferative glomerulonephritis can occur with other diseases such as lupus nephritis and the recently revealed genetic heterogeneity suggest different pathogentic mechanisms. Mesangioproliferative glomerulonephritis is a histomorphological diagnosis characterized by mesangial accumulation of cells and IgA deposits. Clinical picture is dominated by hematuria which is often accompanied by proteinuria and decline of renal function.
Although most renal biopsies show IgA deposits, a small group of non-IgA mesangioproliferative glomerulonephritis can be distinguished.[Error: Macro 'ref' doesn't exist]
Primary and secodary forms can be distinguished. The latter includes diseases such as lupus nephropathy.
Genetic factors can be grouped into risk factors and those that cause diseases that can be accompanied by mesangioproliferative glomerulonephritis. For instance, the deletion of the CFRH1 und CFRH3 genes is a well characterized risk factor, and diseases associated with mesangioproliferative glomerulonephritis include Wiskott–Aldrich syndrome, complement component C1q deficiency and Schimke Immunoosseous dysplasia.
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