Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders
Moldiag Diseases Genes Support Contact

Gout susceptibility 1

The disposition to develop gout disease is hereditary. For type 1, the gene ABCG2 is responsible.

Systematic

Hyperuricemia
Gout susceptibility 1
ABCG2
Hyperuricemic nephropathy
Kelley-Seegmiller syndrome
Lesch-Nyhan syndrome

References:

1.

Dehghan A et al. (2008) Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study.

external link
2.

Matsuo H et al. (2009) Common defects of ABCG2, a high-capacity urate exporter, cause gout: a function-based genetic analysis in a Japanese population.

external link
3.

Martinon F et al. (2006) Gout-associated uric acid crystals activate the NALP3 inflammasome.

external link
4.

None (1979) Genetics of hyperuricemia in families with gout.

external link
5.

Healey LA et al. (1967) Hyperuricemia in Filipinos: interaction of heredity and environment.

external link
6.

HAUGE M et al. (1955) Heredity in gout and hyperuricemia.

external link
7.

None (1960) Heredity in primary gout.

external link
8.

NEEL JV et al. (1965) STUDIES ON HYPERURICEMIA. II. A RECONSIDERATION OF THE DISTRIBUTION OF SERUM URIC ACID VALUES IN THE FAMILIES OF SMYTH, COTTERMAN, AND FREYBERG.

external link
9.

Cheng LS et al. (2004) Genomewide scan for gout in taiwanese aborigines reveals linkage to chromosome 4q25.

external link
10.

Woodward OM et al. (2011) ABCG transporters and disease.

external link
11.

Köttgen A et al. (2013) Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.

external link
12.

OMIM.ORG article

Omim 138900 external link
Update: Aug. 14, 2020
Copyright © 2005-2024 by Center for Nephrology and Metabolic Disorders, Dr. Mato Nagel, MD
Albert-Schweitzer-Ring 32, D-02943 Weißwasser, Germany, Tel.: +49-3576-287922, Fax: +49-3576-287944
Sitemap | Webmail | Disclaimer | Privacy Issues | Website Credits