Hypernephroma is a renal cell carcinoma with histomorphological characteristic clear cells. Often we find somatic mutations underlying this disease. However if those tumors occur at multiple sites and bilateral a germline mutation in the genes listed here has to be taken into account.
1. |
Erlandsson R et al. (1988) Do human renal cell carcinomas arise by a double-loss mechanism? |
2. |
Kovacs G et al. (1987) Specific chromosome aberration in human renal cell carcinoma. |
3. |
King CR et al. (1987) Proximal 3p deletion in renal cell carcinoma cells from a patient with von Hippel-Lindau disease. |
4. |
Szücs S et al. (1987) Deletion 3p: the only chromosome loss in a primary renal cell carcinoma. |
5. |
Harris P et al. (1986) Mapping by chromosome sorting of several gene probes, including c-myc, to the derivative chromosomes of a 3;8 translocation associated with familial renal cancer. |
6. |
Carroll PR et al. (1987) Abnormalities at chromosome region 3p12-14 characterize clear cell renal carcinoma. |
7. |
Teyssier JR et al. (1986) Recurrent deletion of the short arm of chromosome 3 in human renal cell carcinoma: shift of the c-raf 1 locus. |
8. |
Kovacs G et al. (1988) Loss of der(3) in renal carcinoma cells of a patient with constitutional t(3;12). |
9. |
Kovacs G et al. (1988) Recurrent genomic rearrangements are not at the fragile sites on chromosomes 3 and 5 in human renal cell carcinomas. |
10. |
Miles J et al. (1988) Genomic defects in nonfamilial renal cell carcinoma. Possible specific chromosome change. |
11. |
Yoshida MA et al. (1986) Rearrangement of chromosome 3 in renal cell carcinoma. |
12. |
Gemmill RM et al. (1989) A 1.5-megabase restriction map surrounding MYC does not include the translocation breakpoint in familial renal cell carcinoma. |
13. |
Linehan M et al. (1989) Improved detection of allele loss in renal cell carcinomas after removal of leukocytes by immunologic selection. |
14. |
Kovacs G et al. (1989) Clonal chromosome abnormalities in tumor cells from patients with sporadic renal cell carcinomas. |
15. |
Kovacs G et al. (1988) Consistent chromosome 3p deletion and loss of heterozygosity in renal cell carcinoma. |
16. |
Zbar B et al. () Loss of alleles of loci on the short arm of chromosome 3 in renal cell carcinoma. |
17. |
van der Hout AH et al. (1988) Direct molecular analysis of a deletion of 3p in tumors from patients with sporadic renal cell carcinoma. |
18. |
Levinson AK et al. (1990) Familial renal cell carcinoma: hereditary or coincidental? |
19. |
Sato Y et al. (2013) Integrated molecular analysis of clear-cell renal cell carcinoma. |
20. |
None (2013) Comprehensive molecular characterization of clear cell renal cell carcinoma. |
21. |
Hino O et al. (1993) Spontaneous and radiation-induced renal tumors in the Eker rat model of dominantly inherited cancer. |
22. |
Lott ST et al. (1998) Physical and functional mapping of a tumor suppressor locus for renal cell carcinoma within chromosome 3p12. |
23. |
Bodmer D et al. (1998) An alternative route for multistep tumorigenesis in a novel case of hereditary renal cell cancer and a t(2;3)(q35;q21) chromosome translocation. |
24. |
Koolen MI et al. (1998) A familial case of renal cell carcinoma and a t(2;3) chromosome translocation. |
25. |
Kovacs G et al. (1997) The Heidelberg classification of renal cell tumours. |
26. |
van den Berg A et al. (1997) Involvement of multiple loci on chromosome 3 in renal cell cancer development. |
27. |
Teh BT et al. (1997) Familial non-VHL non-papillary clear-cell renal cancer. |
28. |
Geurts JM et al. (1997) Expression of reciprocal hybrid transcripts of HMGIC and FHIT in a pleomorphic adenoma of the parotid gland. |
29. |
Motzer RJ et al. (1996) Renal-cell carcinoma. |
30. |
Lyons AR et al. (1977) Hypernephroma in two brothers. |
31. |
Fairchild RS et al. (1979) Neuroblastoma, pheochromocytoma, and renal cell carcinoma. Occurrence in a single patient. |
32. |
Li FP et al. (1993) Clinical and genetic studies of renal cell carcinomas in a family with a constitutional chromosome 3;8 translocation. Genetics of familial renal carcinoma. |
33. |
Sanchez Y et al. (1994) A tumor suppressor locus within 3p14-p12 mediates rapid cell death of renal cell carcinoma in vivo. |
34. |
Gnarra JR et al. (1994) Mutations of the VHL tumour suppressor gene in renal carcinoma. |
35. |
Jakesz R et al. (1978) [Familial bilateral renal-cell carcinoma and cerebellar haemangioma (author's transl)]. |
36. |
Li FP et al. (1982) Familial renal carcinoma. |
37. |
Pathak S et al. (1982) Familial renal cell carcinoma with a 3;11 chromosome translocation limited to tumor cells. |
38. |
Neel BG et al. (1982) Two human c-onc genes are located on the long arm of chromosome 8. |
39. |
Wang N et al. (1984) Involvement of band 3p14 in t(3;8) hereditary renal carcinoma. |
40. |
Franksson C et al. (1972) Renal carcinoma (hypernephroma) occurring in 5 siblings. |
41. |
Woodward ER et al. (2000) Familial clear cell renal cell carcinoma (FCRC): clinical features and mutation analysis of the VHL, MET, and CUL2 candidate genes. |
42. |
Van Erp F et al. (2003) Chromosome 3 translocations and the risk to develop renal cell cancer: a Dutch intergroup study. |
43. |
Kuiper RP et al. (2003) Upregulation of the transcription factor TFEB in t(6;11)(p21;q13)-positive renal cell carcinomas due to promoter substitution. |
44. |
Yamaguchi S et al. (2003) The allelic loss of chromosome 3p25 with c-myc gain is related to the development of clear-cell renal cell carcinoma. |
45. |
Bodmer D et al. (2002) Understanding familial and non-familial renal cell cancer. |
46. |
Bodmer D et al. (2002) Cytogenetic and molecular analysis of early stage renal cell carcinomas in a family with a translocation (2;3)(q35;q21). |
47. |
Braun WE et al. (1975) The association of W17 with familial renal cell carcinoma. |
48. |
Podolski J et al. (2001) Characterization of a familial RCC-associated t(2;3)(q33;q21) chromosome translocation. |
49. |
Druck T et al. (2001) The DIRC1 gene at chromosome 2q33 spans a familial RCC-associated t(2;3)(q33;q21) chromosome translocation. |
50. |
Eleveld MJ et al. (2001) Molecular analysis of a familial case of renal cell cancer and a t(3;6)(q12;q15). |
51. |
Bertolotto C et al. (2011) A SUMOylation-defective MITF germline mutation predisposes to melanoma and renal carcinoma. |
53. |
Pathak S et al. (1986) Specific chromosome anomalies and predisposition to human breast, renal cell, and colorectal carcinoma. |
54. |
Maranchie JK et al. (2004) Solid renal tumor severity in von Hippel Lindau disease is related to germline deletion length and location. |
55. |
Gemmill RM et al. (1998) The hereditary renal cell carcinoma 3;8 translocation fuses FHIT to a patched-related gene, TRC8. |
56. |
Ohta M et al. (1996) The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormal in digestive tract cancers. |
57. |
Cohen AJ et al. (1979) Hereditary renal-cell carcinoma associated with a chromosomal translocation. |
58. |
Kobayashi T et al. (1995) A germline insertion in the tuberous sclerosis (Tsc2) gene gives rise to the Eker rat model of dominantly inherited cancer. |
59. |
Schimke RN et al. (2010) Paraganglioma, neuroblastoma, and a SDHB mutation: Resolution of a 30-year-old mystery. |
60. |
Rebouissou S et al. (2005) Germline hepatocyte nuclear factor 1alpha and 1beta mutations in renal cell carcinomas. |
61. |
None (1953) Silent adenocarcinoma of the kidney with solitary metastases occurring in brothers. |
62. |
Peña-Llopis S et al. (2012) BAP1 loss defines a new class of renal cell carcinoma. |
63. |
Varela I et al. (2011) Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma. |
64. |
Dalgliesh GL et al. (2010) Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes. |
65. |
Shimizu M et al. (1990) Introduction of normal chromosome 3p modulates the tumorigenicity of a human renal cell carcinoma cell line YCR. |
66. |
Liu J et al. (2009) Analysis of Drosophila segmentation network identifies a JNK pathway factor overexpressed in kidney cancer. |
67. |
Hoffmann NE et al. (2008) External validation of IMP3 expression as an independent prognostic marker for metastatic progression and death for patients with clear cell renal cell carcinoma. |
68. |
Poland KS et al. (2007) A constitutional balanced t(3;8)(p14;q24.1) translocation results in disruption of the TRC8 gene and predisposition to clear cell renal cell carcinoma. |
69. |
Cascón A et al. (2007) Loss of the actin regulator HSPC300 results in clear cell renal cell carcinoma protection in Von Hippel-Lindau patients. |
70. |
van der Hout AH et al. (1991) The region of common allelic losses in sporadic renal cell carcinoma is bordered by the loci D3S2 and THRB. |
71. |
Jiang Z et al. (2006) Analysis of RNA-binding protein IMP3 to predict metastasis and prognosis of renal-cell carcinoma: a retrospective study. |
72. |
Krambeck AE et al. (2006) B7-H4 expression in renal cell carcinoma and tumor vasculature: associations with cancer progression and survival. |
73. |
Ogawa O et al. (1991) Allelic loss at chromosome 3p characterizes clear cell phenotype of renal cell carcinoma. |
74. |
Walker C et al. (1992) Predisposition to renal cell carcinoma due to alteration of a cancer susceptibility gene. |
76. |
Everitt JI et al. (1992) Hereditary renal cell carcinoma in the Eker rat: a rodent familial cancer syndrome. |
77. |
Ogawa O et al. (1992) Allelic losses at chromosome 17p in human renal cell carcinoma are inversely related to allelic losses at chromosome 3p. |
78. |
Anglard P et al. (1992) Molecular and cellular characterization of human renal cell carcinoma cell lines. |
79. |
Bodmer D et al. (2003) Disruption of a novel gene, DIRC3, and expression of DIRC3-HSPBAP1 fusion transcripts in a case of familial renal cell cancer and t(2;3)(q35;q21). |
80. |
OMIM.ORG article Omim 144700 |
81. |
Wikipedia article Wikipedia EN (Renal_cell_carcinoma) |