Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders

Lipoprotein glomerulopathy

Lipoprotein glomerulopathy is a rare autosomal recessive disorder found predominantly among people from China and Japan. It is extremely rare among Caucasians. Some mutations of the APOE gene cause lipoprotein deposition in glomeruli, which results in proteinuria and progressive renal failure.

Systematic

Hereditary glomerular disease
Fibronectin glomerulopathy
Glomerulonephritis
Glomerulosclerosis
Lipoprotein glomerulopathy
APOE
Myoclonus-nephropathy syndrome
Nephritic syndrome
Nephrotic syndrome

References:

1.

Oikawa S et al. (1997) Apolipoprotein E Sendai (arginine 145-->proline): a new variant associated with lipoprotein glomerulopathy.

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2.

Rovin BH et al. (2007) APOE Kyoto mutation in European Americans with lipoprotein glomerulopathy.

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3.

Saito T et al. (2006) Impact of lipoprotein glomerulopathy on the relationship between lipids and renal diseases.

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4.

OMIM.ORG article

Omim 611771 [^]
5.

Orphanet article

Orphanet ID 329481 [^]
Update: May 9, 2019