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Hyperalphalipoproteinemia 1

Hyperalphalipoproteinemia 1 is a Hyperlipoproteinemia characterized by hight HDL levels which is caused by mutations of the CETP gene. Mode of inheritance is variable dominant as well as recessive forms are described. Affected probands are characterized by longevity.

Clinical Findings

In general, probands with hyperalphalipoproteinemia are characterized by a lower-than-average risk of cardiovascular disease. In hyperalphalipoproteinemia 1 not only HDL are increased, but also LDL decreased further enhancing the anti-atherogenic effect. Probands stand out because of their longevity.


Hyperalphalipoproteinemia is characterized by a specific lipid electrophoresis pattern, a height alpha peak. Additionally the size of the HDL particles is greater than average and the concentration of LDL-particles lower.


Apolipoprotein deficiency
Betalipoprotein deficiency
Epigenetic dyslipidemia
Hyperalphalipoproteinemia 1
Hyperalphalipoproteinemia 2



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OMIM.ORG article

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Update: May 9, 2019
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