Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders

Pregnancy exacerbated hypertension

A mutation of the mineralocorticoid receptor causes increased sensity for aldosterone and also progesterone. Thus women during pregnancy or administration of progesterone-containing contraceptives will develop severe hypertension. Only one mutation (p.S810L) is described so far to have this effect. Inheritance is autosomal dominant.

Systematic

Pseudohyperaldosteronism
Apparent mineralocorticoid excess
Liddle syndrome
Pregnancy exacerbated hypertension
NR3C2

References:

1.

Geller DS et al. (2000) Activating mineralocorticoid receptor mutation in hypertension exacerbated by pregnancy.

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2.

OMIM.ORG article

Omim 605115 [^]
Update: May 10, 2019