Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders
Moldiag Diseases Genes Support Contact

Resistance to trypanosoma brucei

A genetic variation identified in the APOL1 gene causes an increased susceptibility to FSGS but at the same time it helps heterozygous carriers to defend against trypanosoma brucei infections.

Systematic

Disposition to infections
Disorders of mRNA editing
Familial candidiasis
Genetic susceptibility to aspergillosis
HIV resistance
IRAK4 deficiency
Invasive pneumococcal disease
Measles infection susceptibility
Meningococcal infection susceptibility
Resistance to trypanosoma brucei
APOL1
Septic shock
Susceptibility to bacteremia 1
Susceptibility to malaria
Susceptibility to mycobacterial diseases
Susceptibility to pseudomonas infection
X-linked mendelian susceptibility to mycobacterial diseases due to IKBKG deficiency

References:

1.

Duchateau PN et al. (2001) Apolipoprotein L gene family: tissue-specific expression, splicing, promoter regions; discovery of a new gene.

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2.

Page NM et al. (2001) The human apolipoprotein L gene cluster: identification, classification, and sites of distribution.

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3.

Mimmack ML et al. (2002) Gene expression analysis in schizophrenia: reproducible up-regulation of several members of the apolipoprotein L family located in a high-susceptibility locus for schizophrenia on chromosome 22.

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4.

Monajemi H et al. (2002) The apolipoprotein L gene cluster has emerged recently in evolution and is expressed in human vascular tissue.

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5.

Vanhamme L et al. (2003) Apolipoprotein L-I is the trypanosome lytic factor of human serum.

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6.

Pérez-Morga D et al. (2005) Apolipoprotein L-I promotes trypanosome lysis by forming pores in lysosomal membranes.

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7.

Genovese G et al. (2010) Association of trypanolytic ApoL1 variants with kidney disease in African Americans.

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8.

Duchateau PN et al. (1997) Apolipoprotein L, a new human high density lipoprotein apolipoprotein expressed by the pancreas. Identification, cloning, characterization, and plasma distribution of apolipoprotein L.

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9.

OMIM.ORG article

Omim 603743 external link
Update: Aug. 14, 2020
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