Disposition to infections

This group includes hereditary genetic changes that affect the susceptibility or resistance to infectious diseases. Those disorders include general disturbances of the infectious defense mechanisms. Those disturbances result in a general susceptibility to all or a wider group of infections. There are also genetic variations that specifically affect resistance or susceptibility to a specific infectious agent.

Systematic

Hereditary diseases
	Disposition to infections
		Disorders of mRNA editing
			APOBEC1
			APOBEC2
			APOBEC3A
			APOBEC3B
			APOBEC3C
			APOBEC3D
			APOBEC3F
			APOBEC3G
			APOBEC3H
			APOBEC4
		Familial candidiasis
			CLEC6A
			Familial candidiasis 2
				CARD9
			Familial candidiasis 3
			Familial candidiasis 4
				CLEC7A
			Familial candidiasis 5
				IL17RA
			Familial candidiasis 6
				IL17F
			Familial candidiasis 8
				TRAF3IP2
			Familial candidiasis 9
				IL17RC
		Genetic susceptibility to aspergillosis
			CLEC1A
			CLEC7A
		HIV resistance
			AIDS progression
				IFNG
			CCR5
			CXCR1
			HIV-1 viremia susceptibility
				HLA-C
			HIV1 susceptibility
				IL10
		IRAK4 deficiency
			IRAK4
		Invasive pneumococcal disease
			Invasive pneumococcal disease 1
				IRAK4
			Invasive pneumococcal disease 2
				IKBKG
			Invasive pneumococcal disease 3
				TIRAP
		Measles infection susceptibility
			CD46
		Meningococcal infection susceptibility
			C3
			C5
			C7
			C8A
			C8B
			C8G
			C9
			CD46
			CFB
			CFD
			CFH
			CFP
		Resistance to trypanosoma brucei
			APOL1
		Septic shock
			TNF
		Susceptibility to bacteremia 1
			TIRAP
		Susceptibility to malaria
			FCGR2A
			FCGR2B
			TNF
		Susceptibility to mycobacterial diseases
			TIRAP
			X-linked mendelian susceptibility to mycobacterial diseases due to IKBKG deficiency
				IKBKG
		Susceptibility to pseudomonas infection
			FCGR2A
		X-linked mendelian susceptibility to mycobacterial diseases due to IKBKG deficiency
			IKBKG
	Genetic alterations of drug tolerance
	Hereditary broncho-pulmonary disease
	Hereditary cardiac disease
	Hereditary dermatological disorders
	Hereditary diseases of the hematopoetic system and coagulopathies
	Hereditary endocrinological diseases
	Hereditary immunological disorders
	Hereditary kidney diseases
	Hereditary liver disease
	Hereditary malformations
	Hereditary metabolic diseases
	Hereditary musculoskeletal diseases
	Hereditary neurological disorders
	Hereditary ocular disease and visual impairment
	Hereditary otorhinolaryngological disorders
	Hereditary pancreatic disease
	Hereditary tumors
	Hereditary vascular disease
	Hypertension

References:

1.	Sardinha JF et al. () Genetic risk factors for human susceptibility to infections of relevance in dermatology.

2.	None (2006) Aspects of genetic susceptibility to human infectious diseases.