Graves disease is a hyperthyroidism syndrome associated with goiter, eye disease (orbitopathy), and occasionally a dermopathy referred to as pretibial or localized myxedema. An essential feature of Graves disease are autoantibodies to the thyrotropin receptor (TSHR-Ab) that activate the receptor. That constant unregulated stimulation of the thyroid gland causes excessive hormone synthesis and secretion as well as thyroid growth (causing a diffuse goiter).
Hyperthyroidism | ||||
Familial gestational hyperthyroidism | ||||
Graves disease | ||||
GC | ||||
McCune-Albright syndrom | ||||
Non-autoimmune hyperthyroidism | ||||
Susceptibility to thyrotoxic periodic paralysis 1 | ||||
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