Histamine Intolerance
Histamine Intolerance is an intolerance of ingested histamine probably caused by dysfunction of the two metabolizing enzymes HNMT and DAO. The symptoms are similar to allegic reactions.
Pathogenesis
| Diarrhea | |
 |
In patients with histamine intolerance diarrhea manifests after the ingestion of greater amounts of biogenic amines. |
Systematic
References:
| 1. |
Sasaki Y et al. (2000) Lack of association between atopic asthma and polymorphisms of the histamine H1 receptor, histamine H2 receptor, and histamine N-methyltransferase genes. [^] |
| 2. |
Yan L et al. (2000) Histamine N-methyltransferase pharmacogenetics: association of a common functional polymorphism with asthma. [^] |
| 3. |
Barnes WG et al. (2004) Characterization of a new mRNA species from the human histamine N-methyltransferase gene. [^] |
| 4. |
Sharma S et al. (2005) Lack of association of histamine-N-methyltransferase (HNMT) polymorphisms with asthma in the Indian population. [^] |
| 5. |
Yamauchi K et al. (1994) Structure and function of human histamine N-methyltransferase: critical enzyme in histamine metabolism in airway. [^] |
| 6. |
Price RA et al. (1993) Genetic segregation analysis of red blood cell (RBC) histamine N-methyltransferase (HNMT) activity. [^] |
| 7. |
Aksoy S et al. (1996) Human histamine N-methyltransferase gene: structural characterization and chromosomal location. [^] |
| 8. |
Preuss CV et al. (1998) Human histamine N-methyltransferase pharmacogenetics: common genetic polymorphisms that alter activity. [^] |
| 9. |
OMIM.ORG article Omim 605238 [^] |
| 10. |
Wikipedia article Wikipedia EN (Histamine_intolerance) [^] |
