Histamine Intolerance is an intolerance of ingested histamine probably caused by dysfunction of the two metabolizing enzymes HNMT and DAO. The symptoms are similar to allegic reactions.
In patients with histamine intolerance diarrhea manifests after the ingestion of greater amounts of biogenic amines.
Sasaki Y et al. (2000) Lack of association between atopic asthma and polymorphisms of the histamine H1 receptor, histamine H2 receptor, and histamine N-methyltransferase genes.[^]
Yan L et al. (2000) Histamine N-methyltransferase pharmacogenetics: association of a common functional polymorphism with asthma.[^]
Barnes WG et al. (2004) Characterization of a new mRNA species from the human histamine N-methyltransferase gene.[^]
Sharma S et al. (2005) Lack of association of histamine-N-methyltransferase (HNMT) polymorphisms with asthma in the Indian population.[^]
Yamauchi K et al. (1994) Structure and function of human histamine N-methyltransferase: critical enzyme in histamine metabolism in airway.[^]
Price RA et al. (1993) Genetic segregation analysis of red blood cell (RBC) histamine N-methyltransferase (HNMT) activity.[^]
Aksoy S et al. (1996) Human histamine N-methyltransferase gene: structural characterization and chromosomal location.[^]
Preuss CV et al. (1998) Human histamine N-methyltransferase pharmacogenetics: common genetic polymorphisms that alter activity.[^]
OMIM.ORG articleOmim 605238 [^]
Wikipedia articleWikipedia EN (Histamine_intolerance) [^]