Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders

Histamine Intolerance

Histamine Intolerance is an intolerance of ingested histamine probably caused by dysfunction of the two metabolizing enzymes HNMT and DAO. The symptoms are similar to allegic reactions.

Pathogenesis

G cluster_0 Metabolism tissues (Mediator) cluster_1 Metabolism CNS (Neurotransmitter) a0 L-Histidin a1 Histamine a0:s->a1:n HDC a2 Imidazole acetic acid a1:w->a2:n DAO a3 Tele-methylhistamine a1:e->a3:n HNMT a4 Tele-methylimidazole acetic acid a3:s->a4:n MAO
Histamine metabolism

Symptoms

Diarrhea
In patients with histamine intolerance diarrhea manifests after the ingestion of greater amounts of biogenic amines.

Systematic

Food intolerance
Adult type lactose intolerance
Eosinophil peroxidase deficiency
Fructose intolerance
Fructose malabsorption
Fructose-1,6-bisphosphatase deficiency
Fructosuria
Glucose-Galactose Malabsorption
Histamine Intolerance
AOC1
HNMT
MAOA
MAOB
Lactase deficiency
Lysinuric protein intolerance
Mast cell activation syndrome
Sitosterolemia
Trehalase deficiency

References:

1.

Sasaki Y et al. (2000) Lack of association between atopic asthma and polymorphisms of the histamine H1 receptor, histamine H2 receptor, and histamine N-methyltransferase genes.

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2.

Yan L et al. (2000) Histamine N-methyltransferase pharmacogenetics: association of a common functional polymorphism with asthma.

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3.

Barnes WG et al. (2004) Characterization of a new mRNA species from the human histamine N-methyltransferase gene.

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4.

Sharma S et al. (2005) Lack of association of histamine-N-methyltransferase (HNMT) polymorphisms with asthma in the Indian population.

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5.

Yamauchi K et al. (1994) Structure and function of human histamine N-methyltransferase: critical enzyme in histamine metabolism in airway.

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6.

Price RA et al. (1993) Genetic segregation analysis of red blood cell (RBC) histamine N-methyltransferase (HNMT) activity.

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7.

Aksoy S et al. (1996) Human histamine N-methyltransferase gene: structural characterization and chromosomal location.

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8.

Preuss CV et al. (1998) Human histamine N-methyltransferase pharmacogenetics: common genetic polymorphisms that alter activity.

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9.

OMIM.ORG article

Omim 605238 [^]
10.

Wikipedia article

Wikipedia EN (Histamine_intolerance) [^]
Update: May 11, 2019