Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders

Benign hyperproreninemia

The disorder is caused by a premature stop codon (p.R387X), and is characterized by elevated prorenin plasma levels, which pathophysiological consequences are yet to be determined.

Systematic

Hypertension
ACE
ACE2
AGT
Benign hyperproreninemia
REN
Monogenic hypertension
Preeclampsia
Salt-sensitive essential hypertension
VEGFC

References:

1.

van Hooft IM et al. (1991) Renal hemodynamics and the renin-angiotensin-aldosterone system in normotensive subjects with hypertensive and normotensive parents.

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2.

Villard E et al. (1994) A mutant renin gene in familial elevation of prorenin.

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3.

OMIM.ORG article

Omim 179820 [^]
Update: May 10, 2019