Transient neonatal diabetes mellitus is an autosomal dominant disorder caused by mutations of the ABCC8 gene. The clinical variation within a family can vary significantly from transient or permanent neonatal diabetes mellitus to a typical type 2 diabetes of adulthood.
The disease is cause by an activating mutation of the ABCC8 gene.
The disease can be treated by sulfonyl urea.
|Neonatal diabetes mellitus|
|Neonatal diabetes mellitus with congenital hypothyroidism|
|Permanent neonatal diabetes mellitus|
|Renal cysts and diabetes (RCAD)|
|Transient neonatal diabetes mellitus 1|
|Transient neonatal diabetes mellitus 2|
|Transient neonatal diabetes mellitus 3|
|X-linked immunodysregulation, polyendocrinopathy, and enteropathy|
Takeda A et al. (2003) Cutting edge: role of IL-27/WSX-1 signaling for induction of T-bet through activation of STAT1 during initial Th1 commitment.