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Center for Nephrology and Metabolic Disorders
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Hyperinsulinemic hypoglycemia 2

Congenital hyperinsulinism, nesidioblastosis is the most common cause of persistent hypoglycemia in infancy which is caused by increased insulin secretion despite of low blood glycose levels. The most important complication is cerebral damage as a result of prolonged hypoglycemia. Type 2 of the disease is caused by KCNJ11 mutations.

Systematic

Hyperinsulinemic hypoglycemia
HNF1A
HNF4A
Hyperinsulinemic hypoglycemia 1
Hyperinsulinemic hypoglycemia 2
KCNJ11
Hyperinsulinemic hypoglycemia 3
Hyperinsulinemic hypoglycemia 4
Hyperinsulinemic hypoglycemia 5
Hyperinsulinemic hypoglycemia 6
Hyperinsulinemic hypoglycemia 7
Polycystic kidney disease with hyperinsulinemic hypoglycemia

References:

1.

Xiao L et al. (2004) Stat1 controls postnatal bone formation by regulating fibroblast growth factor signaling in osteoblasts.

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2.

Hoskins BE et al. (2007) Transcription factor SIX5 is mutated in patients with branchio-oto-renal syndrome.

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3.

Boucher CA et al. (1995) A novel homeodomain-encoding gene is associated with a large CpG island interrupted by the myotonic dystrophy unstable (CTG)n repeat.

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4.

Mühlethaler JP et al. (1967) [Acute hyperparathyroidism in primary parathyroid hyperplasia].

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5.

Graber AL et al. (1968) Familial hyperparathyroidism. Medical and surgical considerations.

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6.

OMIM.ORG article

Omim 600946 external link
7.

Orphanet article

Orphanet ID 122095 external link
8.

NCBI article

NCBI 2690 external link
Update: Aug. 14, 2020
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