Monogenic hypertension

Monogenic hypertension is caused by alteration of a single gene and therefore shows Mendelian patterns of inheritance.

Epidemiology

Mendelian forms of hypertension are rare. They account for less than 1%.

Systematic

Hypertension
	ACE
	ACE2
	AGT
	Benign hyperproreninemia
	Monogenic hypertension
		Apparent mineralocorticoid excess
			HSD11B2
		Glucocorticoid triggered hypertension
			NR3C1
		Hyperaldosteronism
			Conn syndrome
				ATP1A1
				ATP2B3
				CACNA1D
				CACNA1H
				CTNNB1
				KCNJ5
			Glucocorticoid triggered hypertension
				NR3C1
			Hyperaldosteronism type 1
				CYP11B1
				CYP11B2
			Hyperaldosteronism type 2
				CLCN2
			Hyperaldosteronism type 3
				KCNJ5
			Hyperaldosteronism type 4
				CACNA1D
				CACNA1H
		Hypertension and brachydactyly syndrome
			PDE3A
		Liddle syndrome
			NEDD4
			NEDD4L
			NR3C2
			OXSR1
			SCNN1B
			SCNN1G
			STK39
		Pseudohypoaldosteronism
			Pseudohypoaldosteronism type 2
				CUL3
				KLHL3
				WNK1
				WNK4
			Pseudohypoaldosteronism type1
				NR3C2
				SCNN1A
				SCNN1B
				SCNN1G
	Preeclampsia
	Salt-sensitive essential hypertension
	VEGFC

References:

1.	None (2004) Present status of genetic mechanisms in hypertension.