Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders

Diabetic nephropathy

Diabetic nephropathy is characterized by progressive renal demage asociated with diabetes.

Test Strategy

It is useful to define a risk factor at the beginning of a diagnostic process.

Pathogenesis

There are different pathophysiologic processes leading to renal demage in diabetes. The classic glomerulosclerosis (Kimmelstiel-Wilson) along with tubulointerstitial processes mainly connected to recurrent infections and vascular demages.The molecular pathophysiologic link from gene to disease is not clear yet. Nevertheless there are different genetic risk factors in discussion.

Systematic

Diabetes mellitus
Diabetic nephropathy
ACE
AGT
AKR1B1
Diabetic retinopathy
Gestational diabetes mellitus
Hereditary susceptibility to diabetes
Insulin resistance
MODY diabetes
Mitochondrial diabetes
Neonatal diabetes mellitus
Noninsulin-dependent diabetes mellitus 1
Pancreatogenic diabetes
Severe obesity and type 2 diabetes
Susceptibility to type 1 diabetes 01

References:

1.

Nakajima K et al. (2002) Chemokine receptor genotype is associated with diabetic nephropathy in Japanese with type 2 diabetes.

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2.

Sale MM et al. (2006) Genetic determinants of albuminuria and renal disease in diabetes mellitus.

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3.

OMIM.ORG article

Omim 603933 [^]
4.

Wikipedia article

Wikipedia EN (Diabetic_nephropathy) [^]
Update: May 9, 2019