Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders
Moldiag Diseases Genes Support Contact

Arteriosclerosis

Arteriosclerosis is a vascular disease in the arterial system that causes many organ disorders including myocardial infarction, cerebral infarction etc.

Test Strategy

There are lot of investigation developed that allow us to determine localization and extention of arteriosclerotic lesions. But to clarify the pathogenesis only risk factors can be established.

Pathogenesis

The pathogenesis is not fully understood. There are several risk factors known until now: these include environmantal factors (smoking, diet), thrombotic and lipid disorders.

Systematic

Hereditary vascular disease
Arteriosclerosis
APOB
APOE
HABP2
LDLR
LPA
MTHFR
PON1
SLC3A1
Diabetic microangiopathy 4
Hereditary Angioedema
Hereditary lymphedema
STING-associated vasculopathy with onset in infancy
Sneddon syndrome
Susceptibility to arteriovenous malformations of the brain
Thromboembolic diseases
Vascular calcification
Vasculitis due to ADA2 deficiency

References:

1.

Lusis AJ et al. (2004) Genetic basis of atherosclerosis: part I: new genes and pathways.

external link
2.

Baker WF et al. (1999) Treatment of hereditary and acquired thrombophilic disorders.

external link
3.

Nitu-Whalley IC et al. (1999) Acquired von Willebrand syndrome--report of 10 cases and review of the literature.

external link
4.

Santagostino E et al. (2000) Guidelines on replacement therapy for haemophilia and inherited coagulation disorders in Italy.

external link
5.

None (2000) Coagulation and bleeding disorders: review and update.

external link
6.

Wikipedia article

Wikipedia EN (TMEM138) external link
Update: Aug. 14, 2020
Copyright © 2005-2021 by Center for Nephrology and Metabolic Disorders, Dr. Mato Nagel, MD
Albert-Schweitzer-Ring 32, D-02943 Weißwasser, Germany, Tel.: +49-3576-287922, Fax: +49-3576-287944
Sitemap | Webmail | Disclaimer | Privacy Issues