Molekulargenetische Diagnostik
Praxis Dr. Mato Nagel

Agouti-related-Protein

Das AGRP-Gen kodiert ein Protein, welches in der Signaltransduktion von den Melanocortin-Rezeptoren 3 und 4 eingebunden ist. Mutationen können eine spät einsetzende autosomal dominante Form der Adipositas und eine ausgesprochene Schlankheit hervorrufen.

Diagnostik:

Clinic Untersuchungsmethoden Familienuntersuchung
Bearbeitungszeit 5
Probentyp genomic DNA
Research Untersuchungsmethoden Direkte Sequenzierung der proteinkodierenden Bereiche eines Gens
Bearbeitungszeit 25
Probentyp genomic DNA
Clinic Untersuchungsmethoden Hochdurchsatz-Sequenzierung
Bearbeitungszeit 25
Probentyp genomic DNA

Krankheiten:

Vererbte Magersucht
AGRP
Spätmanifeste Adipositas
AGRP

Referenzen:

1.

Kitamura T et. al. (2006) Forkhead protein FoxO1 mediates Agrp-dependent effects of leptin on food intake.

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2.

Shutter JR et. al. (1997) Hypothalamic expression of ART, a novel gene related to agouti, is up-regulated in obese and diabetic mutant mice.

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3.

Ollmann MM et. al. (1997) Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein.

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4.

Graham M et. al. (1997) Overexpression of Agrt leads to obesity in transgenic mice.

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5.

Katsuki A et. al. (2001) Plasma levels of agouti-related protein are increased in obese men.

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6.

Brown AM et. al. (2001) The gene structure and minimal promoter of the human agouti related protein.

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7.

Argyropoulos G et. al. (2002) A polymorphism in the human agouti-related protein is associated with late-onset obesity.

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8.

Marks DL et. al. (2004) Ala67Thr polymorphism in the Agouti-related peptide gene is associated with inherited leanness in humans.

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9.

Luquet S et. al. (2005) NPY/AgRP neurons are essential for feeding in adult mice but can be ablated in neonates.

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10.

Andrews ZB et. al. (2008) UCP2 mediates ghrelin's action on NPY/AgRP neurons by lowering free radicals.

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11.

Atasoy D et. al. (2012) Deconstruction of a neural circuit for hunger.

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12.

Krashes MJ et. al. (2014) An excitatory paraventricular nucleus to AgRP neuron circuit that drives hunger.

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