Molekulargenetische Diagnostik
Praxis Dr. Mato Nagel

ABCG1

Das ABCG1-kodiert eine ATP-abhängiges Transportprotein, welches für den Transport von Cholesterin und Phospholipiden verantwortlich ist. Epigenetische Modifikation in diesem Gen wurde im Zusammenhang mit Fettstoffwechselstörungen beobachtet.

Diagnostik:

Clinic Untersuchungsmethoden Familienuntersuchung
Bearbeitungszeit 5
Probentyp genomic DNA
Research Untersuchungsmethoden Direkte Sequenzierung der proteinkodierenden Bereiche eines Gens
Bearbeitungszeit 25
Probentyp genomic DNA
Clinic Untersuchungsmethoden Hochdurchsatz-Sequenzierung
Bearbeitungszeit 25
Probentyp genomic DNA
Research Untersuchungsmethoden Methylisierungsanalyse
Bearbeitungszeit 25
Probentyp genomic DNA

Krankheiten:

Epigenetische Dyslipidämie
ABCG1
CPT1A
MIR33B
SREBF1
TNIP1
TNNT1

Referenzen:

1.

Braun KV et. al. (2016) The role of DNA methylation in dyslipidaemia: A systematic review.

[^]
2.

Pfeiffer L et. al. (2015) DNA methylation of lipid-related genes affects blood lipid levels.

[^]
3.

Guay SP et. al. (2014) Epipolymorphisms within lipoprotein genes contribute independently to plasma lipid levels in familial hypercholesterolemia.

[^]
4.

Yvan-Charvet L et. al. (2010) ATP-binding cassette transporters and HDL suppress hematopoietic stem cell proliferation.

[^]
5.

Chen H et. al. (1996) Cloning of the cDNA for a human homologue of the Drosophila white gene and mapping to chromosome 21q22.3.

[^]
6.

Savary S et. al. (1996) Molecular cloning of a mammalian ABC transporter homologous to Drosophila white gene.

[^]
7.

Croop JM et. al. (1997) Isolation and characterization of a mammalian homolog of the Drosophila white gene.

[^]
8.

Klucken J et. al. (2000) ABCG1 (ABC8), the human homolog of the Drosophila white gene, is a regulator of macrophage cholesterol and phospholipid transport.

[^]
9.

Langmann T et. al. (2000) Genomic organization and characterization of the promoter of the human ATP-binding cassette transporter-G1 (ABCG1) gene.

[^]
10.

Lorkowski S et. al. (2001) Genomic sequence and structure of the human ABCG1 (ABC8) gene.

[^]
11.

Jakobsson T et. al. (2009) GPS2 is required for cholesterol efflux by triggering histone demethylation, LXR recruitment, and coregulator assembly at the ABCG1 locus.

[^]
12.

Peng P et. al. (2014) A preliminary study of the relationship between promoter methylation of the ABCG1, GALNT2 and HMGCR genes and coronary heart disease.

[^]

 

 
Ihre Nachricht: