SPRY2-Gen

Milillo A et al. (2015) A SPRY2 mutation leading to MAPK/ERK pathway inhibition is associated with an autosomal dominant form of IgA nephropathy.

Hacohen N et al. (1998) sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways.

Lim J et al. (2000) Sprouty proteins are targeted to membrane ruffles upon growth factor receptor tyrosine kinase activation. Identification of a novel translocation domain.

Gross I et al. (2001) Mammalian sprouty proteins inhibit cell growth and differentiation by preventing ras activation.

Yusoff P et al. (2002) Sprouty2 inhibits the Ras/MAP kinase pathway by inhibiting the activation of Raf.

Egan JE et al. (2002) The bimodal regulation of epidermal growth factor signaling by human Sprouty proteins.

Lim J et al. (2002) The cysteine-rich sprouty translocation domain targets mitogen-activated protein kinase inhibitory proteins to phosphatidylinositol 4,5-bisphosphate in plasma membranes.

Hanafusa H et al. (2002) Sprouty1 and Sprouty2 provide a control mechanism for the Ras/MAPK signalling pathway.

Ding W et al. (2003) Functional analysis of the human Sprouty2 gene promoter.

Shim K et al. (2005) Sprouty2, a mouse deafness gene, regulates cell fate decisions in the auditory sensory epithelium by antagonizing FGF signaling.

Taketomi T et al. (2005) Loss of mammalian Sprouty2 leads to enteric neuronal hyperplasia and esophageal achalasia.

Klein OD et al. (2006) Sprouty genes control diastema tooth development via bidirectional antagonism of epithelial-mesenchymal FGF signaling.

Metzger RJ et al. (2008) The branching programme of mouse lung development.

Tang N et al. (2011) Control of mitotic spindle angle by the RAS-regulated ERK1/2 pathway determines lung tube shape.

NCBI article

OMIM.ORG article