Molekulargenetische Diagnostik
Praxis Dr. Mato Nagel

Protein sel-1 Homolog 1

Diagnostik:

Research Untersuchungsmethoden Familienuntersuchung
Bearbeitungszeit 5
Probentyp genomic DNA
Research Untersuchungsmethoden Direkte Sequenzierung der proteinkodierenden Bereiche eines Gens
Bearbeitungszeit 25
Probentyp genomic DNA
Clinic Untersuchungsmethoden Hochdurchsatz-Sequenzierung
Bearbeitungszeit 25
Probentyp genomic DNA

Krankheiten:

Referenzen:

1.

Grant B et. al. (1996) The Caenorhabditis elegans sel-1 gene, a negative regulator of lin-12 and glp-1, encodes a predicted extracellular protein.

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2.

Grant B et. al. (1997) Structure, function, and expression of SEL-1, a negative regulator of LIN-12 and GLP-1 in C. elegans.

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3.

Biunno I et. al. (1997) Isolation of a pancreas-specific gene located on human chromosome 14q31: expression analysis in human pancreatic ductal carcinomas.

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4.

Donoviel DB et. al. (1999) SEL-1L maps to human chromosome 14, near the insulin-dependent diabetes mellitus locus 11.

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5.

Harada Y et. al. (1999) Complete cDNA sequence and genomic organization of a human pancreas-specific gene homologous to Caenorhabditis elegans sel-1.

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6.

Cattaneo M et. al. (2004) Identification of a region within SEL1L protein required for tumour growth inhibition.

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7.

Odom DT et. al. (2007) Tissue-specific transcriptional regulation has diverged significantly between human and mouse.

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8.

Kaneko M et. al. (2007) A different pathway in the endoplasmic reticulum stress-induced expression of human HRD1 and SEL1 genes.

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9.

Mueller B et. al. (2008) SEL1L nucleates a protein complex required for dislocation of misfolded glycoproteins.

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10.

Francisco AB et. al. (2011) Haploid insufficiency of suppressor enhancer Lin12 1-like (SEL1L) protein predisposes mice to high fat diet-induced hyperglycemia.

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