ATP-Bindungskassette sub-familie G member 2
Das ABCG2-Gen kodiert ein Trasnportprotein. Verschiedene Variationen sind im Zusammenhang mit verändertem Metabolismus von Medikamenten beschrieben worden. Außerdem scheines eine Rolle bei der Entwicklung der Hyperurikämie und Gicht zu spielen.
Gentests:
Forschung |
Untersuchungsmethoden |
Familienuntersuchung |
Bearbeitungszeit |
5 Tage |
Probentyp |
genomische DNS |
Verknüpfte Erkrankungen:
Referenzen:
1. |
Dehghan A et al. (2008) Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study.
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2. |
Zelinski T et al. (2012) ABCG2 null alleles define the Jr(a-) blood group phenotype.
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3. |
Saison C et al. (2012) Null alleles of ABCG2 encoding the breast cancer resistance protein define the new blood group system Junior.
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4. |
Wang F et al. (2010) hsa-miR-520h downregulates ABCG2 in pancreatic cancer cells to inhibit migration, invasion, and side populations.
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5. |
Woodward OM et al. (2009) Identification of a urate transporter, ABCG2, with a common functional polymorphism causing gout.
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6. |
Maekawa K et al. (2006) Genetic variation and haplotype structure of the ABC transporter gene ABCG2 in a Japanese population.
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7. |
Jonker JW et al. (2005) The breast cancer resistance protein BCRP (ABCG2) concentrates drugs and carcinogenic xenotoxins into milk.
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8. |
Krishnamurthy P et al. (2004) The stem cell marker Bcrp/ABCG2 enhances hypoxic cell survival through interactions with heme.
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9. |
Jonker JW et al. (2002) The breast cancer resistance protein protects against a major chlorophyll-derived dietary phototoxin and protoporphyria.
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10. |
Ozvegy C et al. (2002) Characterization of drug transport, ATP hydrolysis, and nucleotide trapping by the human ABCG2 multidrug transporter. Modulation of substrate specificity by a point mutation.
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11. |
Eisenblätter T et al. (2002) A new multidrug resistance protein at the blood-brain barrier.
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12. |
Bailey-Dell KJ et al. (2001) Promoter characterization and genomic organization of the human breast cancer resistance protein (ATP-binding cassette transporter G2) gene.
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13. |
Ozvegy C et al. (2001) Functional characterization of the human multidrug transporter, ABCG2, expressed in insect cells.
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14. |
Miyake K et al. (1999) Molecular cloning of cDNAs which are highly overexpressed in mitoxantrone-resistant cells: demonstration of homology to ABC transport genes.
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15. |
Doyle LA et al. (1998) A multidrug resistance transporter from human MCF-7 breast cancer cells.
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16. |
Allikmets R et al. (1998) A human placenta-specific ATP-binding cassette gene (ABCP) on chromosome 4q22 that is involved in multidrug resistance.
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17. |
Matsuo H et al. (2009) Common defects of ABCG2, a high-capacity urate exporter, cause gout: a function-based genetic analysis in a Japanese population.
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18. |
Sims-Mourtada J et al. (2007) Sonic Hedgehog promotes multiple drug resistance by regulation of drug transport.
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19. |
NCBI article
NCBI 9429
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20. |
OMIM.ORG article
Omim 603756
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Update: 14. August 2020