Molekulargenetische Diagnostik
Praxis Dr. Mato Nagel

Protocadherin Fat 1

Diagnostik:

Clinic Untersuchungsmethoden Familienuntersuchung
Bearbeitungszeit 5
Probentyp genomic DNA
Clinic Untersuchungsmethoden Direkte Sequenzierung der proteinkodierenden Bereiche eines Gens
Bearbeitungszeit 25
Probentyp genomic DNA

Krankheiten:

Referenzen:

1.

Hortsch M et. al. (1991) Cell and substrate adhesion molecules in Drosophila.

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2.

Mahoney PA et. al. (1991) The fat tumor suppressor gene in Drosophila encodes a novel member of the cadherin gene superfamily.

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3.

Bryant PJ et. al. (1988) Mutations at the fat locus interfere with cell proliferation control and epithelial morphogenesis in Drosophila.

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4.

Dunne J et. al. (1995) Molecular cloning and tissue expression of FAT, the human homologue of the Drosophila fat gene that is located on chromosome 4q34-q35 and encodes a putative adhesion molecule.

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5.

Katoh Y et. al. (2006) Comparative integromics on FAT1, FAT2, FAT3 and FAT4.

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6.

Ishikawa HO et. al. (2008) Four-jointed is a Golgi kinase that phosphorylates a subset of cadherin domains.

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7.

Morris LG et. al. (2013) Recurrent somatic mutation of FAT1 in multiple human cancers leads to aberrant Wnt activation.

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