OGG1-Gen
Das OGG1-Gen kodiert ein mitochondriales Enzym, welches wahrscheinlich für die Beseitigung der schädlichen Wirkungen von Sauerstoffradikalen verantwortlich ist. In Nierenzellkarzinomen wurde eine somatische Mutation dieses Gens nachgewiesen.
Gentests:
Forschung |
Untersuchungsmethoden |
Familienuntersuchung |
Bearbeitungszeit |
5 Tage |
Probentyp |
genomische DNS |
Verknüpfte Erkrankungen:
Referenzen:
1. |
Audebert M et al. (2000) Alterations of the DNA repair gene OGG1 in human clear cell carcinomas of the kidney.
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2. |
Kohno T et al. (1998) Genetic polymorphisms and alternative splicing of the hOGG1 gene, that is involved in the repair of 8-hydroxyguanine in damaged DNA.
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3. |
Tani M et al. (1998) Genomic structure and chromosomal localization of the mouse Ogg1 gene that is involved in the repair of 8-hydroxyguanine in DNA damage.
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4. |
Kuo FC et al. (1997) Augmented expression of a human gene for 8-oxoguanine DNA glycosylase (MutM) in B lymphocytes of the dark zone in lymph node germinal centers.
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5. |
Bjorâs M et al. (1997) Opposite base-dependent reactions of a human base excision repair enzyme on DNA containing 7,8-dihydro-8-oxoguanine and abasic sites.
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6. |
Roldán-Arjona T et al. (1997) Molecular cloning and functional expression of a human cDNA encoding the antimutator enzyme 8-hydroxyguanine-DNA glycosylase.
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7. |
Radicella JP et al. (1997) Cloning and characterization of hOGG1, a human homolog of the OGG1 gene of Saccharomyces cerevisiae.
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8. |
Rosenquist TA et al. (1997) Cloning and characterization of a mammalian 8-oxoguanine DNA glycosylase.
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9. |
Lu R et al. (1997) A mammalian DNA repair enzyme that excises oxidatively damaged guanines maps to a locus frequently lost in lung cancer.
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10. |
Arai K et al. (1997) Cloning of a human homolog of the yeast OGG1 gene that is involved in the repair of oxidative DNA damage.
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11. |
Aburatani H et al. (1997) Cloning and characterization of mammalian 8-hydroxyguanine-specific DNA glycosylase/apurinic, apyrimidinic lyase, a functional mutM homologue.
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12. |
Perillo B et al. (2008) DNA oxidation as triggered by H3K9me2 demethylation drives estrogen-induced gene expression.
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13. |
Kovtun IV et al. (2007) OGG1 initiates age-dependent CAG trinucleotide expansion in somatic cells.
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14. |
Trapp C et al. (2007) Deficiency of the Cockayne syndrome B (CSB) gene aggravates the genomic instability caused by endogenous oxidative DNA base damage in mice.
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15. |
Wang CL et al. (2006) The hOGG1 Ser326Cys gene polymorphism is associated with decreased insulin sensitivity in subjects with normal glucose tolerance.
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16. |
Banerjee A et al. (2005) Structure of a repair enzyme interrogating undamaged DNA elucidates recognition of damaged DNA.
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17. |
Ishida T et al. (1999) Structure and chromosome location of human OGG1.
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18. |
Orphanet article
Orphanet ID 484183
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19. |
NCBI article
NCBI 4968
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20. |
OMIM.ORG article
Omim 601982
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Update: 14. August 2020