Molekulargenetische Diagnostik
Praxis Dr. Mato Nagel

OGG1-Gen

Das OGG1-Gen kodiert ein mitochondriales Enzym, welches wahrscheinlich für die Beseitigung der schädlichen Wirkungen von Sauerstoffradikalen verantwortlich ist. In Nierenzellkarzinomen wurde eine somatische Mutation dieses Gens nachgewiesen.

Diagnostik:

Research Untersuchungsmethoden Familienuntersuchung
Bearbeitungszeit 5
Probentyp genomic DNA
Research Untersuchungsmethoden Direkte Sequenzierung der proteinkodierenden Bereiche eines Gens
Bearbeitungszeit 25
Probentyp genomic DNA
Clinic Untersuchungsmethoden Hochdurchsatz-Sequenzierung
Bearbeitungszeit 25
Probentyp genomic DNA

Krankheiten:

Nichtpapilläres Nierenzellkarzinom
DIRC2
FLCN
HNF1A
HNF1B
OGG1
RNF139
VHL

Referenzen:

1.

Ishida T et al. (1999) Structure and chromosome location of human OGG1.

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2.

Audebert M et al. (2000) Alterations of the DNA repair gene OGG1 in human clear cell carcinomas of the kidney.

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3.

Banerjee A et al. (2005) Structure of a repair enzyme interrogating undamaged DNA elucidates recognition of damaged DNA.

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4.

Wang CL et al. (2006) The hOGG1 Ser326Cys gene polymorphism is associated with decreased insulin sensitivity in subjects with normal glucose tolerance.

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5.

Trapp C et al. (2007) Deficiency of the Cockayne syndrome B (CSB) gene aggravates the genomic instability caused by endogenous oxidative DNA base damage in mice.

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6.

Kovtun IV et al. (2007) OGG1 initiates age-dependent CAG trinucleotide expansion in somatic cells.

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7.

Perillo B et al. (2008) DNA oxidation as triggered by H3K9me2 demethylation drives estrogen-induced gene expression.

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8.

Aburatani H et al. (1997) Cloning and characterization of mammalian 8-hydroxyguanine-specific DNA glycosylase/apurinic, apyrimidinic lyase, a functional mutM homologue.

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9.

Arai K et al. (1997) Cloning of a human homolog of the yeast OGG1 gene that is involved in the repair of oxidative DNA damage.

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10.

Lu R et al. (1997) A mammalian DNA repair enzyme that excises oxidatively damaged guanines maps to a locus frequently lost in lung cancer.

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11.

Rosenquist TA et al. (1997) Cloning and characterization of a mammalian 8-oxoguanine DNA glycosylase.

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12.

Radicella JP et al. (1997) Cloning and characterization of hOGG1, a human homolog of the OGG1 gene of Saccharomyces cerevisiae.

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13.

Roldán-Arjona T et al. (1997) Molecular cloning and functional expression of a human cDNA encoding the antimutator enzyme 8-hydroxyguanine-DNA glycosylase.

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14.

Bjorâs M et al. (1997) Opposite base-dependent reactions of a human base excision repair enzyme on DNA containing 7,8-dihydro-8-oxoguanine and abasic sites.

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15.

Kuo FC et al. (1997) Augmented expression of a human gene for 8-oxoguanine DNA glycosylase (MutM) in B lymphocytes of the dark zone in lymph node germinal centers.

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16.

Tani M et al. (1998) Genomic structure and chromosomal localization of the mouse Ogg1 gene that is involved in the repair of 8-hydroxyguanine in DNA damage.

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17.

Kohno T et al. (1998) Genetic polymorphisms and alternative splicing of the hOGG1 gene, that is involved in the repair of 8-hydroxyguanine in damaged DNA.

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