Monoaminoxidase A
Das MAOA-Gen kodiert ein mitochondriales Enzym, welches für die oxydative Deaminierung von Aminen verantwortlich ist. Mutationen führen zum x-chromosomal rezessiven Brunnder-Syndrom. Ein Zusammenhang mit der Histaminintoleranz wird auch diskutiert.
Diagnostik:
Krankheiten:
Referenzen:
1. |
Deckert J et al. (1999) Excess of high activity monoamine oxidase A gene promoter alleles in female patients with panic disorder.
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Shih JC et al. (1999) Monoamine oxidase: from genes to behavior.
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3. |
Gilad Y et al. (2002) Evidence for positive selection and population structure at the human MAO-A gene.
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4. |
Desautels A et al. (2002) Evidence for a genetic association between monoamine oxidase A and restless legs syndrome.
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5. |
Caspi A et al. (2002) Role of genotype in the cycle of violence in maltreated children.
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6. |
Fossella J et al. (2002) Assessing the molecular genetics of attention networks.
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7. |
Fan J et al. (2003) Mapping the genetic variation of executive attention onto brain activity.
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8. |
Cohen IL et al. (2003) Association of autism severity with a monoamine oxidase A functional polymorphism.
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9. |
Chen ZY et. al. (1992) Organization of the human monoamine oxidase genes and long-range physical mapping around them.
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10. |
Chen K et. al. (2004) A spontaneous point mutation produces monoamine oxidase A/B knock-out mice with greatly elevated monoamines and anxiety-like behavior.
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11. |
Newman TK et al. (2005) Monoamine oxidase A gene promoter variation and rearing experience influences aggressive behavior in rhesus monkeys.
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12. |
Passamonti L et al. (2006) Monoamine oxidase-a genetic variations influence brain activity associated with inhibitory control: new insight into the neural correlates of impulsivity.
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13. |
Meyer-Lindenberg A et al. (2006) Neural mechanisms of genetic risk for impulsivity and violence in humans.
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14. |
Hotamisligil GS et al. (1991) Human monoamine oxidase A gene determines levels of enzyme activity.
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15. |
Ou XM et al. (2006) Monoamine oxidase A and repressor R1 are involved in apoptotic signaling pathway.
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16. |
Guo G et al. (2008) The VNTR 2 repeat in MAOA and delinquent behavior in adolescence and young adulthood: associations and MAOA promoter activity.
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17. |
McDermott R et al. (2009) Monoamine oxidase A gene (MAOA) predicts behavioral aggression following provocation.
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18. |
Grimsby J et. al. (1991) Human monoamine oxidase A and B genes exhibit identical exon-intron organization.
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19. |
Whibley A et. al. (2010) Deletion of MAOA and MAOB in a male patient causes severe developmental delay, intermittent hypotonia and stereotypical hand movements.
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20. |
Cohen IL et al. (2011) Autism severity is associated with child and maternal MAOA genotypes.
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21. |
Sims KB et al. (1989) Monoamine oxidase deficiency in males with an X chromosome deletion.
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22. |
Lan NC et al. (1989) Human monoamine oxidase A and B genes map to Xp 11.23 and are deleted in a patient with Norrie disease.
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23. |
Levy ER et. al. (1989) Localization of human monoamine oxidase-A gene to Xp11.23-11.4 by in situ hybridization: implications for Norrie disease.
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24. |
Ozelius L et al. (1988) Human monoamine oxidase gene (MAOA): chromosome position (Xp21-p11) and DNA polymorphism.
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25. |
de la Chapelle A et al. (1985) Norrie disease caused by a gene deletion allowing carrier detection and prenatal diagnosis.
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26. |
Kochersperger LM et. al. (1986) Assignment of genes for human monoamine oxidases A and B to the X chromosome.
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27. |
Denney RM et. al. (1982) Human liver MAO-A and MAO-B separated by immunoaffinity chromatography with MAO-B-specific monoclonal antibody.
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28. |
Pintar JE et al. (1981) Gene for monoamine oxidase type A assigned to the human X chromosome.
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29. |
Castro Costa MR et al. (1980) Properties of monoamine oxidase in control and Lesch-Nyhan fibroblasts.
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30. |
Nöthen MM et al. (1995) Association analysis of the monoamine oxidase A gene in bipolar affective disorder by using family-based internal controls.
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31. |
Cases O et al. (1995) Aggressive behavior and altered amounts of brain serotonin and norepinephrine in mice lacking MAOA.
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32. |
Kawada Y et al. (1995) Possible association between monoamine oxidase A gene and bipolar affective disorder.
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33. |
Lim LC et al. (1994) Monoamine oxidase A gene and bipolar affective disorder.
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34. |
Brunner HG et al. (1993) Abnormal behavior associated with a point mutation in the structural gene for monoamine oxidase A.
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35. |
Brunner HG et al. (1993) X-linked borderline mental retardation with prominent behavioral disturbance: phenotype, genetic localization, and evidence for disturbed monoamine metabolism.
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36. |
Lenders JW et. al. (1996) Specific genetic deficiencies of the A and B isoenzymes of monoamine oxidase are characterized by distinct neurochemical and clinical phenotypes.
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37. |
Sabol SZ et al. (1998) A functional polymorphism in the monoamine oxidase A gene promoter.
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Update: 23. Juni 2016