Molekulargenetische Diagnostik
Praxis Dr. Mato Nagel

Wachtumshormon-Releasinghormon

Das von GHRH kodierte Hormon stimuriert über den Releasinghormonrezeptor GHRHR die Sekretion von Wachstumshormon.

Diagnostik:

Clinic Untersuchungsmethoden Familienuntersuchung
Bearbeitungszeit 5
Probentyp genomic DNA
Clinic Untersuchungsmethoden Direkte Sequenzierung der proteinkodierenden Bereiche eines Gens
Bearbeitungszeit 25
Probentyp genomic DNA
Clinic Untersuchungsmethoden Hochdurchsatz-Sequenzierung
Bearbeitungszeit 25
Probentyp genomic DNA

Krankheiten:

Isolierter rezessiver Wachstumshormonmangel Typ 1B
GH1
GHRH
GHRHR

Referenzen:

1.

Russell-Aulet M et al. (1999) In vivo semiquantification of hypothalamic growth hormone-releasing hormone (GHRH) output in humans: evidence for relative GHRH deficiency in aging.

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2.

Kiaris H et al. (1999) Growth hormone-releasing hormone: an autocrine growth factor for small cell lung carcinoma.

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3.

Gianotti L et al. (2000) Arginine counteracts the inhibitory effect of recombinant human insulin-like growth factor I on the somatotroph responsiveness to growth hormone-releasing hormone in humans.

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4.

Busto R et al. (2002) The expression of growth hormone-releasing hormone (GHRH) and splice variants of its receptor in human gastroenteropancreatic carcinomas.

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5.

Halmos G et al. (2002) Expression of growth hormone-releasing hormone and its receptor splice variants in human prostate cancer.

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6.

Letsch M et al. (2003) Growth hormone-releasing hormone (GHRH) antagonists inhibit the proliferation of androgen-dependent and -independent prostate cancers.

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7.

Jessup SK et al. (2003) Sexual dimorphism of growth hormone (GH) regulation in humans: endogenous GH-releasing hormone maintains basal GH in women but not in men.

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8.

Kanashiro CA et al. (2003) Inhibition of mutant p53 expression and growth of DMS-153 small cell lung carcinoma by antagonists of growth hormone-releasing hormone and bombesin.

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9.

Rao VV et al. (1991) The gene for human growth hormone-releasing factor (GHRF) maps to or near chromosome 20p12.

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10.

Shohat M et al. (1991) Deletion of 20p 11.23----pter with normal growth hormone-releasing hormone genes.

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11.

Mitrakou A et al. (1985) Heterogeneity of growth-hormone deficiency.

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12.

Riddell DC et al. (1985) Chromosomal assignment of human sequences encoding arginine vasopressin-neurophysin II and growth hormone releasing factor.

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13.

Ling N et al. (1985) Growth hormone releasing factors.

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14.

Thorner MO et al. (1988) Acceleration of growth rate in growth hormone-deficient children treated with human growth hormone-releasing hormone.

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15.

Mayo KE et al. (1985) Gene encoding human growth hormone-releasing factor precursor: structure, sequence, and chromosomal assignment.

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16.

Gubler U et al. (1983) Cloning and sequence analysis of cDNA for the precursor of human growth hormone-releasing factor, somatocrinin.

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17.

Thorner MO et al. (1982) Somatotroph hyperplasia. Successful treatment of acromegaly by removal of a pancreatic islet tumor secreting a growth hormone-releasing factor.

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18.

Scheithauer BW et al. (1984) Ectopic secretion of a growth hormone-releasing factor. Report of a case of acromegaly with bronchial carcinoid tumor.

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19.

Pérez Jurado LA et al. (1994) Genetic mapping of the human growth hormone-releasing factor gene (GHRF) using two intragenic polymorphisms detected by PCR amplification.

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20.

Zimmerman D et al. (1993) Congenital gigantism due to growth hormone-releasing hormone excess and pituitary hyperplasia with adenomatous transformation.

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21.

Flavell DM et al. (1996) Dominant dwarfism in transgenic rats by targeting human growth hormone (GH) expression to hypothalamic GH-releasing factor neurons.

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