Phospholipase A2 Rezeptor 1
Das PLA2R1-Gen kodiert eine sezernierte Phospholipase. Antikörper gegen dieses Protein werden bei membranöser Glomerulonephritis gesehen. Polymorphismen in diesem Gen sind mit der isiopathischen menbranösen Glomerulonephritis assoziiert.
Gentests:
Klinisch |
Untersuchungsmethoden |
Familienuntersuchung |
Bearbeitungszeit |
5 Tage |
Probentyp |
genomische DNS |
Verknüpfte Erkrankungen:
Referenzen:
1. |
Debiec H et al. (2014) Immunopathogenesis of membranous nephropathy: an update.
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2. |
Ancian P et al. (1995) The human 180-kDa receptor for secretory phospholipases A2. Molecular cloning, identification of a secreted soluble form, expression, and chromosomal localization.
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3. |
Beck LH et al. (2009) M-type phospholipase A2 receptor as target antigen in idiopathic membranous nephropathy.
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4. |
Wuttke M et al. (2016) Insights into kidney diseases from genome-wide association studies.
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5. |
Sinico RA et al. (2016) Immunology of membranous nephropathy: from animal models to humans.
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6. |
Radice A et al. (2016) Clinical usefulness of autoantibodies to M-type phospholipase A2 receptor (PLA2R) for monitoring disease activity in idiopathic membranous nephropathy (IMN).
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7. |
Li Y et al. (2016) Single-nucleotide polymorphisms in the PLA2R1 gene are associated with systemic lupus erythematosus and lupus nephritis in a Chinese Han population.
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8. |
Hihara K et al. (2016) Anti-Phospholipase A2 Receptor (PLA2R) Antibody and Glomerular PLA2R Expression in Japanese Patients with Membranous Nephropathy.
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9. |
Gentile G et al. (2016) Novel Biomarkers for Renal Diseases? None for the Moment (but One).
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10. |
Francis JM et al. (2016) Membranous Nephropathy: A Journey From Bench to Bedside.
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11. |
Ruggenenti P et al. (2015) Anti-Phospholipase A2 Receptor Antibody Titer Predicts Post-Rituximab Outcome of Membranous Nephropathy.
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12. |
Ronco P et al. (2015) Pathophysiological advances in membranous nephropathy: time for a shift in patient's care.
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13. |
Ronco P et al. (2015) Membranous nephropathy: A fairy tale for immunopathologists, nephrologists and patients.
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14. |
Li ZQ et al. (2015) Efficacy and safety of tacrolimus vs. cyclophosphamide for idiopathic membranous nephropathy: A meta-analysis of Chinese adults.
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15. |
Lai WL et al. (2015) Membranous nephropathy: a review on the pathogenesis, diagnosis, and treatment.
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16. |
None (2015) Anti-phospholipase A2 Receptor Antibody and Immunosuppression in Membranous Nephropathy: More Evidence for Pathogenicity of Anti-phospholipase A2 Receptor Autoantibodies.
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17. |
Smyth LJ et al. (2014) Genetic and epigenetic factors influencing chronic kidney disease.
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18. |
Lv J et al. (2013) Interaction between PLA2R1 and HLA-DQA1 variants associates with anti-PLA2R antibodies and membranous nephropathy.
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19. |
NCBI article
NCBI 22925
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20. |
OMIM.ORG article
Omim 604939
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21. |
Wikipedia Artikel
Wikipedia DE (Phospholipase-A2-Rezeptor)
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Update: 14. August 2020