Molekulargenetische Diagnostik
Praxis Dr. Mato Nagel

BMI-beeinflussender genetischer Faktor

Die Gruppe umfasst genetische Loci eine quantitative Beziehung zum Body-Mass-Index (BMI) besitzen.

Gliederung

Fettleibigkeit
Autosomal dominante Adipositas
BMI-beeinflussender genetischer Faktor
Genetischer BMI-Faktor 14
FTO
Frühzeitig einsetzende Adipositas
Neigung zu Fettleibigkeit
Schwere Fettsucht
Schwere Fettsucht mit Typ 2 Diabetes
Spätmanifeste Adipositas

Referenzen:

1.

Meyre D et. al. (2009) Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations.

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2.

Masud S et. al. (2003) Effect of the peroxisome proliferator activated receptor-gamma gene Pro12Ala variant on body mass index: a meta-analysis.

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3.

Hallstrand TS et. al. (2005) Genetic pleiotropy between asthma and obesity in a community-based sample of twins.

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4.

Hanson RL et al. (1998) An autosomal genomic scan for loci linked to type II diabetes mellitus and body-mass index in Pima Indians.

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5.

Deeb SS et. al. (1998) A Pro12Ala substitution in PPARgamma2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity.

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6.

Rice T et. al. (1999) Familial aggregation of body mass index and subcutaneous fat measures in the longitudinal Québec family study.

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7.

Valve R et. al. (1999) Two polymorphisms in the peroxisome proliferator-activated receptor-gamma gene are associated with severe overweight among obese women.

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8.

Hsueh WC et. al. (2001) Genome-wide scan of obesity in the Old Order Amish.

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9.

Feitosa MF et. al. (2002) Quantitative-trait loci influencing body-mass index reside on chromosomes 7 and 13: the National Heart, Lung, and Blood Institute Family Heart Study.

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10.

Atwood LD et. al. (2002) Genomewide linkage analysis of body mass index across 28 years of the Framingham Heart Study.

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11.

Platte P et. al. (2003) A study of linkage and association of body mass index in the Old Order Amish.

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12.

Yanagiya T et. al. (2007) Association of single-nucleotide polymorphisms in MTMR9 gene with obesity.

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13.

Walley AJ et. al. (2009) The genetic contribution to non-syndromic human obesity.

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14.

Speliotes EK et. al. (2010) Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.

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15.

Kilpeläinen TO et. al. (2011) Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile.

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16.

Shungin D et. al. (2015) New genetic loci link adipose and insulin biology to body fat distribution.

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17.

Locke AE et. al. (2015) Genetic studies of body mass index yield new insights for obesity biology.

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