Molekulargenetische Diagnostik
Praxis Dr. Mato Nagel

Genetischer BMI-Faktor 14

Genetische Veränderungen im FTO-Gen führen in rezesiver Form zu Übergewicht.

Gliederung

BMI-beeinflussender genetischer Faktor
Genetischer BMI-Faktor 14
FTO

Referenzen:

1.

Loos RJ et. al. (2008) Common variants near MC4R are associated with fat mass, weight and risk of obesity.

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2.

Willer CJ et. al. (2009) Six new loci associated with body mass index highlight a neuronal influence on body weight regulation.

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3.

Hardy R et. al. (2010) Life course variations in the associations between FTO and MC4R gene variants and body size.

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4.

Frayling TM et. al. (2007) A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity.

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5.

Dina C et. al. (2007) Variation in FTO contributes to childhood obesity and severe adult obesity.

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6.

Meyre D et. al. (2009) Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations.

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7.

Claussnitzer M et. al. (2015) FTO Obesity Variant Circuitry and Adipocyte Browning in Humans.

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8.

Kilpeläinen TO et. al. (2011) Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile.

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9.

Renström F et. al. (2009) Replication and extension of genome-wide association study results for obesity in 4923 adults from northern Sweden.

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10.

Ohashi J et. al. (2007) FTO polymorphisms in oceanic populations.

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11.

Wardle J et. al. (2008) Obesity associated genetic variation in FTO is associated with diminished satiety.

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12.

Cecil JE et. al. (2008) An obesity-associated FTO gene variant and increased energy intake in children.

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13.

Jonsson A et. al. (2009) Obesity, FTO gene variant, and energy intake in children.

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14.

Kent P et. al. (2009) Case 3-2009: a 9-month-old boy with seizures.

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15.

Ho AJ et. al. (2010) A commonly carried allele of the obesity-related FTO gene is associated with reduced brain volume in the healthy elderly.

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16.

Yang J et. al. (2012) FTO genotype is associated with phenotypic variability of body mass index.

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