Die Veranlagung für hohe LDL-Cholesterinwerte kann vererbt werden. Unter anderem ist dafür das Gen HMGCR verantwortlich.
1. |
Kathiresan S et al. (2008) Polymorphisms associated with cholesterol and risk of cardiovascular events. |
2. |
Yu CY et al. (2014) HNRNPA1 regulates HMGCR alternative splicing and modulates cellular cholesterol metabolism. |
3. |
None (2004) Genetic polymorphisms and statin therapy. |
4. |
Chasman DI et al. (2004) Pharmacogenetic study of statin therapy and cholesterol reduction. |
5. |
Wang CY et al. (2003) Lovastatin, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, induces apoptosis and differentiation in human anaplastic thyroid carcinoma cells. |
6. |
Sever N et al. (2003) Accelerated degradation of HMG CoA reductase mediated by binding of insig-1 to its sterol-sensing domain. |
7. |
Istvan ES et al. (2001) Structural mechanism for statin inhibition of HMG-CoA reductase. |
8. |
Van Doren M et al. (1998) HMG-CoA reductase guides migrating primordial germ cells. |
9. |
Reynolds GA et al. (1984) HMG CoA reductase: a negatively regulated gene with unusual promoter and 5' untranslated regions. |
10. |
Osborne TF et al. (1985) 5' end of HMG CoA reductase gene contains sequences responsible for cholesterol-mediated inhibition of transcription. |
11. |
Mohandas T et al. (1986) Assignment of human 3-hydroxy-3-methylglutaryl coenzyme A reductase gene to q13----q23 region of chromosome 5. |
12. |
None (1987) Conservation of promoter sequence but not complex intron splicing pattern in human and hamster genes for 3-hydroxy-3-methylglutaryl coenzyme A reductase. |
13. |
Humphries SE et al. (1985) The isolation, characterisation, and chromosomal assignment of the gene for human 3-hydroxy-3-methylglutaryl coenzyme A reductase, (HMG-CoA reductase). |
14. |
Goldstein JL et al. (1990) Regulation of the mevalonate pathway. |
15. |
Aulchenko YS et al. (2009) Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. |
17. |
Teslovich TM et al. (2010) Biological, clinical and population relevance of 95 loci for blood lipids. |
18. |
OMIM.ORG article Omim 142910 |