Die Veranlagung für entzündliche Darmerkrankungen kann vererbt werden. Für den Typ 13 ist das Gen ABCB1 verantwortlich.
1. |
Panwala CM et al. (1998) A novel model of inflammatory bowel disease: mice deficient for the multiple drug resistance gene, mdr1a, spontaneously develop colitis. |
2. |
Brant SR et al. (2003) MDR1 Ala893 polymorphism is associated with inflammatory bowel disease. |
3. |
Ho GT et al. (2006) ABCB1/MDR1 gene determines susceptibility and phenotype in ulcerative colitis: discrimination of critical variants using a gene-wide haplotype tagging approach. |
4. |
Satsangi J et al. (1996) Two stage genome-wide search in inflammatory bowel disease provides evidence for susceptibility loci on chromosomes 3, 7 and 12. |
5. |
Cho JH et al. (1998) Identification of novel susceptibility loci for inflammatory bowel disease on chromosomes 1p, 3q, and 4q: evidence for epistasis between 1p and IBD1. |
6. |
Kim RB et al. (2001) Identification of functionally variant MDR1 alleles among European Americans and African Americans. |
7. |
OMIM.ORG article Omim 612244 |