Molekulargenetische Diagnostik
Praxis Dr. Mato Nagel

Nichtpapilläres Nierenzellkarzinom

Das Hypernephrom ist eine bösartige Nierenerkrankung, die sich histologisch durch klarzellige Carcinomzellen auszeichnet. Meist sind es somatische Mutationen, die ein solches Carcinom auslösen. Wenn allerdings solche Carcinome an verschiedenen Stellen und beidseitig auftreten sollte auch an Keimbahnmutationen in den genannten Genen gedacht werden. Die Vererbung ist dominant allerdings mit unterschiedlicher Penetranz.

Gliederung

Hereditäre Nierentumoren
Hereditäre Leiomyomatose mit Nierenzellkarzinom
Nichtpapilläres Nierenzellkarzinom
DIRC2
FLCN
HNF1A
HNF1B
OGG1
RNF139
VHL
Wilms-Tumor
von Hippel-Lindau-Syndrom

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