In dieser Gruppe werden Erkrankungen zusammengefasst die auf einer Gestörten Wachstumshormonwirkung beruhen. Dabei können Störungen auf den verschiedensten Ebenen der Wachstumshormon-Signalkaskade liegen. Vom Releasing Hormon über das Wachstumshormon bis hin zum Somatomedin C (IGF1) genannten Zytokin. In jedem dieser Signalschritte kann wiederum sowohl das Hormon als auch der Rezeptor betroffen sein.
Für alle Laborteste gilt das Störungen innerhalb der Wachstumshormon-Signalkaskade meist zu einer Erhöhung der Hormonwerte stromauf und einer Erniedrigung strommab führen.
Parameter | Interpretation |
---|---|
GHRH | Erniedrigt bei Störungen in Hypothalamus |
GH | Erniedrigt bei Störungen in der Hypophyse |
IGF1 | Erniedrigt bei Störungen in GH-Signalverarbeitung in peripheren Zellen |
TSH,LH,ACTH,FSH | Erniedrigt bei Störungen der gesamten Hypophyse |
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