Molekulargenetische Diagnostik
Praxis Dr. Mato Nagel

Resistenz gegenüber Trypanosoma brucei

Eine genetische Variation im APOL1-Gen die insbesondere bei Afrikanern vorkommt prädisponiert zu Ausbildung einer FSGS aber schützt heterozygote Anlageträger vor Trypanosoma brucei Infektionen.

Gliederung

Erbliche Infektionsanfälligkeiten
HIV-Resistenz
Masern-Infektanfälligkeit
Meningokokken-Infektanfälligkeit
Resistenz gegenüber Trypanosoma brucei
APOL1
Störungen der mRNA-Editiertfunktion

Referenzen:

1.

Duchateau PN et al. (2001) Apolipoprotein L gene family: tissue-specific expression, splicing, promoter regions; discovery of a new gene.

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2.

Page NM et al. (2001) The human apolipoprotein L gene cluster: identification, classification, and sites of distribution.

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3.

Mimmack ML et al. (2002) Gene expression analysis in schizophrenia: reproducible up-regulation of several members of the apolipoprotein L family located in a high-susceptibility locus for schizophrenia on chromosome 22.

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4.

Monajemi H et al. (2002) The apolipoprotein L gene cluster has emerged recently in evolution and is expressed in human vascular tissue.

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5.

Vanhamme L et al. (2003) Apolipoprotein L-I is the trypanosome lytic factor of human serum.

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6.

Pérez-Morga D et al. (2005) Apolipoprotein L-I promotes trypanosome lysis by forming pores in lysosomal membranes.

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7.

Genovese G et al. (2010) Association of trypanolytic ApoL1 variants with kidney disease in African Americans.

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8.

Duchateau PN et al. (1997) Apolipoprotein L, a new human high density lipoprotein apolipoprotein expressed by the pancreas. Identification, cloning, characterization, and plasma distribution of apolipoprotein L.

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