Patienten mit Schilddrüsenhormonresistenz sind durch eine Struma bei hohen Schilddrüsenhormonspiegel und einer euthyreoten Stoffwechsellage characterisiert. Zur Reduktion des Strumawachstums werden sehr hohe Schilddrüsenhormondosen benötigt. Verschiedene Ursachen der Schilddrüsenhormonresistenz können unterschieden werden. Rezeptordefekte sind am besten untersucht. Weitere Ursachen können ein gestörter Hormontransport durch die Zellmembran, Metabolisierungsstörungen, Störungen beim Eintritt in dien Zellkern und Störungen in den Kofaktoren (RXRA) sein.
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