Molekulargenetische Diagnostik
Praxis Dr. Mato Nagel

Basedow-Krankheit

Morbus Basedow ist eine Hyperthyreose-Syndrom, welches von Struma, Exophthalmus und gelegentlich auch von einem prätibialen Myxödem begleited wird. Ein wichtiges Merkmal sind den TSH-Rezeptor stimmulierende Autoantikörper, die zu einer vermehrten Produktion und Sekretion von Schilddrüsenhormonen und Struma-Wachstum führen.

Gliederung

Störungen des Schilddrüsenhormonsystems
Basedow-Krankheit
GC
Neigung zur thyreotoxischen periodischen Paralyse 1
Neonataler Diabetes mellitus mit angeborener Hypothyreose
Schilddrüsenhormonresistenz

Referenzen:

1.

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2.

Chen QY et al. (1999) HLA-DRB1*08, DRB1*03/DRB3*0101, and DRB3*0202 are susceptibility genes for Graves' disease in North American Caucasians, whereas DRB1*07 is protective.

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3.

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4.

Pearce SH et al. (1999) Further evidence for a susceptibility locus on chromosome 20q13.11 in families with dominant transmission of Graves disease.

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5.

Chen QY et al. (2000) The human leukocyte antigen HLA DRB3*020/DQA1*0501 haplotype is associated with Graves' disease in African Americans.

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6.

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7.

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8.

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9.

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10.

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11.

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12.

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13.

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14.

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15.

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16.

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17.

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18.

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19.

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20.

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21.

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22.

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23.

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24.

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25.

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26.

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27.

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28.

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29.

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30.

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31.

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32.

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33.

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34.

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35.

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36.

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37.

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38.

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