Molekulargenetische Diagnostik
Praxis Dr. Mato Nagel

IgA-Nephropathie

Die IgA-Nephropathie ist die häufigste Form der mesangioproliferativen Glomerulonephritis und der Glomerulonephritiden insgesamt. Immunhistologisch ist es eine mesangioproliferative Glomerulonephritis mit verstärkter IgA-Ablagerung. Meist ist auch im Serum ein erhöhter IgA-Spiegel nachweisbar.

Klinischer Befund

Der Verlauf der IgA-Nephropathie ist individuell sehr unterschiedlich. Während einige Patienten über Jahre stabil bleiben, gelangen andere relativ rasch in das Stadium der terminalen Niereninsuffizienz. Die Ursachen für diese individuellen Unterschiede sind noch bei weitem nicht aufgeklärt. Neben der effektiven Blutdrucksenkung mit einer Blockade des Renin-Angiotensin-Systems und diätetischen Maßnahmen (Polyen-Fettsäuren sog. Fischöl) scheinen auch genetische Faktoren eine Rolle zu spielen.

Gliederung

Mesangioproliferative Glomerulonephritis
CXCR1
IgA-Nephropathie
CFHR1
CFHR3
CFHR5
IgA-Nephropathie Typ 1
IgA-Nephropathie Typ 2
IgA-Nephropathie Typ 3
SPRY2
Komplement C1q-Mangel
Schimke-Dysplasie
Wiskott-Aldrich-Syndrom

Referenzen:

1.

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2.

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7.

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8.

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9.

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29.

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