Molekulargenetische Diagnostik
Praxis Dr. Mato Nagel

Glomerulonephritis

Die Glomerulonephritis ist eine Gruppe pathogenetisch ganz unterschiedlicher Erkrankungen, die eine entzündliche Veränderung des Glomerulums, der Filtrationseinheiten der Niere bewirken. Oft liegt der Erkrankung eine immunologische Störung zu Grunde, deshalb finden sich immer mehr genetische Veränderungen, die für eine solche Erkrankung verantwortlich gemacht werden können.

Diagnosestellung

Die elementaren Symptome einer Glomerulonephritis sind Proteinurie und glomeruläre Hämaturie. Diese Symptome bestimmen auch die klinische Beschreibung als nephrotische oder nephritische Verlaufsform.

Die histopathologie führte nicht nur zu einer präziseren Diagnose sondern erlaubte auch eine Einteilung in morphologische Untergruppen und mit der Immunhistologie wurden auch der Grundstein für ein pathogenetische Einteilung gelegt.

In dem Maße wie die pathophysiologischen Zusammenhänge besser verstanden werden und die genetischen Ursachen der gesthörten immunologischen Vorgänge aufgedeckt werden können erlaubt dies künftig eine subtilere pathogenetische Einteilung.

Gliederung

Hereditäre glomeruläre Nierenerkrankungen
Fibronectin-Glomerulopathie
Glomerulonephritis
C3 Glomerulopathie
C3-Glomerulonephritis
ADAMTS13
C1QA
C1QB
C1QC
C3
CD46
CFB
CFD
CFH
CFHR1
CFHR2
CFHR3
CFHR4
CFHR5
CFI
CLU
DGKE
PIGA
THBD
Dense Deposit Disease
ADAMTS13
C1QA
C1QB
C1QC
C3
CD46
CFB
CFD
CFH
CFHR1
CFHR2
CFHR3
CFHR4
CFHR5
CFI
CLU
DGKE
PIGA
THBD
CFHR5 Nephropathie
CFHR5
Goodpasture-Syndrom
COL4A3
COL4A3BP
COL4A5
Lupus erythematodes Nephritis
C1QA
C1QB
C1QC
CFHR1
CFHR3
Membranoproliferative Glomerulonephritis (MPGN)
ADAMTS13
C1QA
C1QB
C1QC
C3
CD46
CFB
CFD
CFH
CFHR1
CFHR2
CFHR3
CFHR4
CFHR5
CFI
CLU
CR1-Mangel
CR1
DGKE
Komplement C1q-Mangel
C1QA
C1QB
C1QC
Komplement C1s-Mangel
C1S
PIGA
THBD
Membranöse Glomerulonephritis
HLA-DQA1
PLA2R1
Mesangioproliferative Glomerulonephritis
CXCR1
IgA-Nephropathie
CFHR1
CFHR3
CFHR5
IgA-Nephropathie Typ 1
IgA-Nephropathie Typ 2
IgA-Nephropathie Typ 3
SPRY2
Komplement C1q-Mangel
C1QA
C1QB
C1QC
Schimke-Dysplasie
SMARCAL1
Wiskott-Aldrich-Syndrom
WAS
Glomerulosklerose
Lipoprotein-Glomerulopathie
Myoclonus-Nephropathie-Syndrom
Nephritisches Syndrom
Nephrotisches Syndrom

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