Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders

Acanthosis nigricans

Acanthosis nigricans is a grayish brown hyperpigmentation of the skin in body folds such as neck, the armpits, groin, and navel.

Diseases

Alström syndrome
In Alstrom syndrome besides of obesity and diabetes an acanthosis nigricans can be seen.
Crouzon syndrome
Among several other dysmorphic features acanthosis nigricans is typical of Crouzon syndrome, in particular when caused by FGFR3 mutations.
Diabetes mellitus with insulin resistance and acanthosis nigricans
All types of insulin resistance caused by mutations of the insulin receptor gene are accompanied by acanthosis nigricans.
Leprechaunism
Insulin resistance in leprechaunism is accompanied by acanthosis nigricans.
Lipodystrophy
Generalized and partial lipodystrophy may be accompanied by acanthosis nigricans.
Generalized lipodystrophy
Generalized lipodystrophy is accompanied by acanthosis nigricans.
Familial partial lipodystrophy type 2
Partial lipodystrophy 2 is accompanied by acanthosis nigricans.