Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders

Calcinosis

Calcinosis is the calcification (calcium deposition) in soft tissues that is outside the bones.

Pathogenesis

Calcinosis can be caused by local or systemic factors. The former are injuries or injections; the latter hyperparathyroidism or disorders of calcium and phosphate metabolism.

Classification

Several forms of Calcinosis can can be clinically distinguished:

  • c. circumscripta
  • c. cutis
  • c. intervertebralis calcification of nucleus pulposus (often) and anulus fibrosis (rare) of one or many intervertebral disks.
  • tumoral c. sometimes large soft tissue calcifications around big joints like shoulder, elbow, and hip. Symptoms are mainly caused by nerve compression.
  • c. universalis
  • c. metastatica
  • c. interstitialis

Diseases

Hyperphosphatemic familial tumoral calcinosis
Calcinosis tumoralis is caused by prolonged hyperphosphatemia.