Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders

Hepatic fibrosis

Hepatic fibrosis is the tissue response to any kind of chronic liver injury. Matrix components accumulate extracellularly because of an imbalance in their production, deposition, and degradation. Portal hypertension and impaired liver function are the inevitable consequences.

Classification

A congenital form of hepatic fibrosis (CHF) can be distinguished from an acquired form (cirrhosis).

Diseases

Autosomal dominant polycystic kidney disease
Sometimes in ADPKD a CHF may develop as usually observed in ARPKD.
Autosomal recessive polycystic kidney and hepatic disease 1
The liver shows the typical signs of CHF in patients with ARPKD.
Update: June 23, 2016