Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders
The CLEC6A gene encodes a C-type lectin protein, also known as dectin-2. It is an extracellular pathogen pattern receptor that bind alpha-mannan, a polysacharide predominantly found in fungal hyphae. Deficiencies cause severe fungal infections.
| Clinic | Method | Carrier testing |
| Turnaround | 5 days | |
| Specimen type | genomic DNA |
| Research | Method | Genomic sequencing of the entire coding region |
| Turnaround | 25 days | |
| Specimen type | genomic DNA |
| 1. |
Ritter M et al. (2010) Schistosoma mansoni triggers Dectin-2, which activates the Nlrp3 inflammasome and alters adaptive immune responses. 
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| 2. |
Schenten D et al. (2011) The control of adaptive immune responses by the innate immune system.
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| 3. |
Bi L et al. (2010) CARD9 mediates dectin-2-induced IkappaBalpha kinase ubiquitination leading to activation of NF-kappaB in response to stimulation by the hyphal form of Candida albicans.
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| 4. |
Kanazawa N et al. (2004) Molecular cloning of human dectin-2.
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| 5. |
Flornes LM et al. (2004) Identification of lectin-like receptors expressed by antigen presenting cells and neutrophils and their mapping to a novel gene complex.
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| 6. |
Gavino AC et al. (2005) Identification and expression profiling of a human C-type lectin, structurally homologous to mouse dectin-2.
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| 7. |
Saijo S et al. (2010) Dectin-2 recognition of alpha-mannans and induction of Th17 cell differentiation is essential for host defense against Candida albicans.
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| 8. |
Zhu LL et al. (2013) C-type lectin receptors Dectin-3 and Dectin-2 form a heterodimeric pattern-recognition receptor for host defense against fungal infection.
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| 9. |
Yonekawa A et al. (2014) Dectin-2 is a direct receptor for mannose-capped lipoarabinomannan of mycobacteria.
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