HLA class I histocompatibility antigen, C alpha chain
The HLA-C gene encodes an alpha chain of the MHC-I molecule which is present on almost all body cells and presents there intracellular oligopeptides to CD8 T cells. This antigen presentation is importand for development of immunotolerance and defense of virus infections. Variants are ssociated with varous immunological disorders such as autoinflammation and susceptibility to infections.
Genetests:
Related Diseases:
References:
1. |
Goverdhan SV et al. (2005) Association of HLA class I and class II polymorphisms with age-related macular degeneration.
|
2. |
Apps R et al. (2013) Response to Comment on "Influence of HLA-C expression level on HIV control".
|
3. |
Lo Monaco E et al. (2013) Comment on "Influence of HLA-C expression level on HIV control".
|
4. |
Apps R et al. (2013) Influence of HLA-C expression level on HIV control.
|
5. |
Moraru M et al. (2012) Host genetic factors in susceptibility to herpes simplex type 1 virus infection: contribution of polymorphic genes at the interface of innate and adaptive immunity.
|
6. |
O'huigin C et al. (2011) The molecular origin and consequences of escape from miRNA regulation by HLA-C alleles.
|
7. |
Kulkarni S et al. (2011) Differential microRNA regulation of HLA-C expression and its association with HIV control.
|
8. |
et al. (2010) The major genetic determinants of HIV-1 control affect HLA class I peptide presentation.
|
9. |
Thomas R et al. (2009) HLA-C cell surface expression and control of HIV/AIDS correlate with a variant upstream of HLA-C.
|
10. |
Yeo TW et al. (2007) A second major histocompatibility complex susceptibility locus for multiple sclerosis.
|
11. |
Nair RP et al. (2006) Sequence and haplotype analysis supports HLA-C as the psoriasis susceptibility 1 gene.
|
12. |
Cianetti L et al. (1989) Three new class I HLA alleles: structure of mRNAs and alternative mechanisms of processing.
|
13. |
Hiby SE et al. (2004) Combinations of maternal KIR and fetal HLA-C genes influence the risk of preeclampsia and reproductive success.
|
14. |
Khakoo SI et al. (2004) HLA and NK cell inhibitory receptor genes in resolving hepatitis C virus infection.
|
15. |
Walsh EC et al. (2003) An integrated haplotype map of the human major histocompatibility complex.
|
16. |
Yen JH et. al. (2001) Major histocompatibility complex class I-recognizing receptors are disease risk genes in rheumatoid arthritis.
|
17. |
Fan QR et al. (2001) Crystal structure of the human natural killer cell inhibitory receptor KIR2DL1-HLA-Cw4 complex.
|
18. |
Carrington M et al. (1999) HLA and HIV-1: heterozygote advantage and B*35-Cw*04 disadvantage.
|
19. |
Kostyu DD et al. (1997) HLA class I polymorphism: structure and function and still questions.
|
20. |
Elder JT et al. (1994) The genetics of psoriasis.
|
21. |
Sodoyer R et al. (1984) Complete nucleotide sequence of a gene encoding a functional human class I histocompatibility antigen (HLA-CW3).
|
Update: Aug. 14, 2020