NACHT, LRR and PYD domains-containing protein 6
The NLRP6 gene encodes a protein that is involved in innate immunity. It binds viral RNA and activates inflammasomes.
Genetests:
Related Diseases:
References:
1. |
Tschopp J et al. (2003) NALPs: a novel protein family involved in inflammation.
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2. |
Grenier JM et al. (2002) Functional screening of five PYPAF family members identifies PYPAF5 as a novel regulator of NF-kappaB and caspase-1.
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3. |
Elinav E et al. (2011) NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis.
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4. |
Anand PK et al. (2012) NLRP6 negatively regulates innate immunity and host defence against bacterial pathogens.
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5. |
Wlodarska M et al. (2014) NLRP6 inflammasome orchestrates the colonic host-microbial interface by regulating goblet cell mucus secretion.
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6. |
Wang P et al. (2015) Nlrp6 regulates intestinal antiviral innate immunity.
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Update: Aug. 14, 2020