Ubiquitin-like protein ISG15
The ISG15 gene encodes a ubiquitin-like protein which stimmulated by interferon-alpha and -beta activates an optimal immune response to mycobacterial infections. Mutations cause autosomal recessive susceptibility to mycobacterial infections.
Genetests:
Related Diseases:
References:
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Clauss IM et al. (1990) Chromosomal localization of two human genes inducible by interferons, double-stranded RNA, and viruses.
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Meraro D et al. (2002) IFN-stimulated gene 15 is synergistically activated through interactions between the myelocyte/lymphocyte-specific transcription factors, PU.1, IFN regulatory factor-8/IFN consensus sequence binding protein, and IFN regulatory factor-4: characterization of a new subtype of IFN-stimulated response element.
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Zhao C et al. (2005) Human ISG15 conjugation targets both IFN-induced and constitutively expressed proteins functioning in diverse cellular pathways.
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Okumura A et al. (2006) Innate antiviral response targets HIV-1 release by the induction of ubiquitin-like protein ISG15.
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Wong JJ et al. (2006) HERC5 is an IFN-induced HECT-type E3 protein ligase that mediates type I IFN-induced ISGylation of protein targets.
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Okumura A et al. (2008) ISG15 inhibits Ebola VP40 VLP budding in an L-domain-dependent manner by blocking Nedd4 ligase activity.
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Salajegheh M et al. (2010) Interferon-stimulated gene 15 (ISG15) conjugates proteins in dermatomyositis muscle with perifascicular atrophy.
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Bogunovic D et al. (2012) Mycobacterial disease and impaired IFN-γ immunity in humans with inherited ISG15 deficiency.
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Zhang X et al. (2015) Human intracellular ISG15 prevents interferon-α/β over-amplification and auto-inflammation.
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Update: Aug. 14, 2020