NLR family CARD domain-containing protein 4
The NLRC4 gene encodes a protein that is involved in innate immune response to a wide range of pathogens. Mutations cause autosomal dominant autoinflammatory disorders such as AIFEC syndrome and familial cold urticaria 4.
Genetests:
Related Diseases:
References:
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Geddes BJ et al. (2001) Human CARD12 is a novel CED4/Apaf-1 family member that induces apoptosis.
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Karki R et al. (2018) IRF8 Regulates Transcription of Naips for NLRC4 Inflammasome Activation.
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Erttmann SF et al. (2016) Loss of the DNA Damage Repair Kinase ATM Impairs Inflammasome-Dependent Anti-Bacterial Innate Immunity.
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Schieber AM et al. (2015) Disease tolerance mediated by microbiome E. coli involves inflammasome and IGF-1 signaling.
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Hu Z et al. (2015) Structural and biochemical basis for induced self-propagation of NLRC4.
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6. |
Zhang L et al. (2015) Cryo-EM structure of the activated NAIP2-NLRC4 inflammasome reveals nucleated polymerization.
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7. |
Kitamura A et. al. (2014) An inherited mutation in NLRC4 causes autoinflammation in human and mice.
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8. |
Romberg N et al. (2014) Mutation of NLRC4 causes a syndrome of enterocolitis and autoinflammation.
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9. |
Canna SW et al. (2014) An activating NLRC4 inflammasome mutation causes autoinflammation with recurrent macrophage activation syndrome.
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10. |
Hu Z et al. (2013) Crystal structure of NLRC4 reveals its autoinhibition mechanism.
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von Moltke J et al. (2012) Rapid induction of inflammatory lipid mediators by the inflammasome in vivo.
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12. |
Qu Y et al. (2012) Phosphorylation of NLRC4 is critical for inflammasome activation.
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13. |
Zhao Y et al. (2011) The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus.
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14. |
Kofoed EM et al. (2011) Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity.
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15. |
Miao EA et al. (2010) Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria.
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16. |
Franchi L et al. (2006) Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1beta in salmonella-infected macrophages.
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17. |
Mariathasan S et al. (2004) Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf.
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18. |
Damiano JS et al. (2001) CLAN, a novel human CED-4-like gene.
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19. |
Poyet JL et al. (2001) Identification of Ipaf, a human caspase-1-activating protein related to Apaf-1.
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20. |
Zhang B et al. (2014) Viral infection. Prevention and cure of rotavirus infection via TLR5/NLRC4-mediated production of IL-22 and IL-18.
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22. |
Romberg N et al. (2017) NLRC4 inflammasomopathies.
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Update: Aug. 14, 2020